PMID: 12590231Feb 19, 2003Paper

Thermal heterogeneity constitutes a marker for the detection of malignant gastric lesions in vivo

Journal of Clinical Gastroenterology
Christodoulos StefanadisPavlos K Toutouzas

Abstract

Several studies have attempted to investigate the association of thermal difference between malignant tumors and inflammatory benign lesions. In this work, we evaluated whether thermal heterogeneity of solid tumors in the stomach constitutes a marker for the diagnosis of benign, preneoplastic, and malignant lesions. A thermistor probe was used that attached to the distal end of a long and steerable, 3fr-thermography catheter passed through the biopsy channel of the gastroscope and came in touch with the stomach epithelium to measure temperature differences (DeltaT) between normal tissue and various types of lesions. The method was applied in 8 patients with benign hyperplastic gastric lesions, 19 patients with gastritis, 9 patients with peptic ulcer, 7 patients with dysplasia and 11 patients with gastric adenocarcinoma. Progressive changes in DeltaT between hyperplastic gastric lesions, gastritis, ulcer, dysplasia and adenocarcinoma were observed (P < 0.001). Statistical analysis showed that DeltaT greater than 1.7 degrees C, constitutes a crucial point for the diagnosis of malignancy, in stomach lesions, with sensitivity (72%) and specificity (94%). These findings suggest that the detection of DeltaT, between normal tissue and...Continue Reading

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Citations

Apr 12, 2005·International Seminars in Surgical Oncology : ISSO·M SalhabK Mokbel
Apr 6, 2006·International Seminars in Surgical Oncology : ISSO·M SalhabK Mokbel
Apr 2, 2011·Medical Physics·Eugeniusz RokitaGrzegorz Tatoń
Dec 27, 2011·Bio Systems·Jason Yongsheng Chan
Feb 14, 2008·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Qi ZhaoWei Cong
Jul 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ryan M Davis, Warren S Warren
Aug 10, 2016·Nature Communications·J H HankiewiczR E Camley

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