PMID: 8606621Jan 1, 1996Paper

Thermal, mechanical and chemical peripheral sensation in amphibians: opioid and adrenergic effects

Life Sciences
S Willenbring, C W Stevens

Abstract

The acetic acid test (AAT) is a quantifiable assay of the response to noxious chemical stimuli on the hindlimb of the northern grass frog, Rana pipiens. AAT is sensitive to both opioid and adrenergic agonist modulation. The present study introduces the novel use of mechanical and thermal stimulus behavioral assays in comparison with the established acetic acid test in studying nociception in frogs. We evaluated mechanical and thermal responses and their sensitivity to systemic morphine (MOR) or dexmedetomidine (DEX) administrations with comparison to AAT. MOR produced dose-related elevations of response thresholds in all three sensory tests, whereas DEX produced elevations in the thermal and AAT assays but had no effect on sensitivity to non-noxious mechanical stimuli. The results suggest a distinct separation of sensory modalities in the frog similar to that observed in mammals and indicate the usefulness of this amphibian model in further studies of nociception.

Citations

Oct 16, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ewan St John Smith, Gary R Lewin
Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
Feb 13, 2001·Brain Research Bulletin·P B Farel, D L McIlwain
Feb 5, 2003·Journal of the American Veterinary Medical Association·Thelma Lee Gross
Mar 3, 2004·Journal of the American Veterinary Medical Association·Matt R Read
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Craig W Stevens
Jun 22, 2018·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Bruce P Bryant, Fred Kraus
Jul 22, 2010·Journal of Veterinary Pharmacology and Therapeutics·S N WambuguT I Kanui
Nov 3, 2021·Journal of the American Association for Laboratory Animal Science : JAALAS·Laura M MartinelliKurt K Sladky
Nov 11, 2021·Journal of the American Association for Laboratory Animal Science : JAALAS·Jennifer C HausmannKurt K Sladky

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