Thermal mechanisms of millimeter wave stimulation of excitable cells

Biophysical Journal
Mikhail G ShapiroFrancisco Bezanilla

Abstract

Interactions between millimeter waves (MMWs) and biological systems have received increasing attention due to the growing use of MMW radiation in technologies ranging from experimental medical devices to telecommunications and airport security. Studies have shown that MMW exposure alters cellular function, especially in neurons and muscles. However, the biophysical mechanisms underlying such effects are still poorly understood. Due to the high aqueous absorbance of MMW, thermal mechanisms are likely. However, nonthermal mechanisms based on resonance effects have also been postulated. We studied MMW stimulation in a simplified preparation comprising Xenopus laevis oocytes expressing proteins that underlie membrane excitability. Using electrophysiological recordings simultaneously with 60 GHz stimulation, we observed changes in the kinetics and activity levels of voltage-gated potassium and sodium channels and a sodium-potassium pump that are consistent with a thermal mechanism. Furthermore, we showed that MMW stimulation significantly increased the action potential firing rate in oocytes coexpressing voltage-gated sodium and potassium channels, as predicted by thermal terms in the Hodgkin-Huxley model of neurons. Our results sug...Continue Reading

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Citations

Sep 18, 2014·Biophysical Journal·Jeremy S TregerFrancisco Bezanilla
Jun 9, 2016·Biophysical Journal·Joseph Santos-Sacchi, Lei Song
Jun 28, 2016·Journal of Computational Neuroscience·Sarah FribanceChangfeng Tai
Apr 25, 2017·ACS Synthetic Biology·Shaunak SenRichard M Murray
Nov 3, 2018·The European Journal of Neuroscience·Karima Ait OuaresNicola Kuczewski
Sep 22, 2019·International Journal of Environmental Research and Public Health·Myrtill Simkó, Mats-Olof Mattsson
Sep 30, 2018·The Journal of General Physiology·Aaron Corbin-LeftwichLinda M Boland
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·John F BarryRonald L Walsworth
May 14, 2020·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Silvia GhirgaMarco Leonetti
Mar 25, 2017·Journal of Radiation Research·Alexis J HaasChristian Saligaut

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