Thermal Oxide Layer Enhances Crystallinity and Mechanical Properties for Plasma-Sprayed Hydroxyapatite Biomedical Coatings.

ACS Applied Materials & Interfaces
Susmita BoseStuart B Goodman

Abstract

The stability of plasma-sprayed hydroxyapatite (HA) coatings on metallic implants in vivo remains a significant challenge for load-bearing orthopedic implants despite their excellent mechanical and osteoconductive properties. This study focuses on oxide layer formation on the surface of Ti6Al4V samples through furnace heating at 600, 700, and 800 °C for 10 min for optimization of the most effective oxide layer to increase plasma coating crystallinity and improve plasma coating bond strength with the metal surface. The 800 °C heat treatment shows an effective oxide layer which increases coating crystallinity from 64 to 75% and coating adhesive bond strength from 25.9 ± 2.3 to 30.7 ± 1.1 MPa, while simultaneously reducing the dissolution rate of HA coatings. The addition of biologically relevant dopants, MgO and SiO2, show negligible effects on crystallinity and adhesive bond strength on plasma-sprayed HA coatings and additionally show an enhancement effect on osteoblast proliferation and differentiation. Moreover, the inclusion of these additivess shows an increase in osteogenesis in a rat distal femur model after 6 and 10 weeks of implantation. Overall, this study provides a direct solution to improve the crystallinity, adhesiv...Continue Reading

References

Mar 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K SøballeC Bünger
Nov 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P E KeetingB L Riggs
Jan 1, 1993·Acta Orthopaedica Scandinavica. Supplementum·K Søballe
Jun 5, 1998·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·K de GrootJ A Jansen
Feb 9, 2000·American Journal of Physiology. Cell Physiology·H J DonahueC E Yellowley
Aug 16, 2001·Journal of Biomedical Materials Research·L SunA Kucuk
Sep 5, 2002·Journal of Biomedical Materials Research·Limin SunKarlis A Gross
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·N PatelP A Revell
Nov 4, 2004·The Journal of Bone and Joint Surgery. American Volume·Bashir A ZikriaS Steven Yang
Feb 3, 2007·Journal of Biomedical Materials Research. Part a·Zachary SeeleySusmita Bose
Apr 6, 2007·Journal of Materials Science. Materials in Medicine·Jin-Ming WuAkiyoshi Osaka
Jun 29, 2007·Journal of Materials Science. Materials in Medicine·Elena LandiSimone Sprio
Feb 14, 2008·Journal of Materials Science. Materials in Medicine·Weichang XueSusmita Bose
Sep 10, 2013·Trends in Biotechnology·Susmita BoseAmit Bandyopadhyay
Sep 11, 2013·Acta Biomaterialia·Živko MladenovićMaria Ransjö
Dec 20, 2013·The Journal of Advanced Prosthodontics·Ki-Deog ParkHong-Ju Park
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Ying-Fang SuMing-You Shie
Dec 17, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dongxu KeSusmita Bose
Jun 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Dongxu Ke, Susmita Bose
Apr 24, 2018·BioMed Research International·Xuezhi LinShicai Fan

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