Thermal preconditioning before rat arterial balloon injury: limitation of injury and sustained reduction of intimal thickening

Arteriosclerosis, Thrombosis, and Vascular Biology
D G NeschisM A Golden

Abstract

Heat shock proteins (HSPs) are a family of highly conserved proteins, essential to cell survival, that are induced during times of physiological stress. These proteins, when induced, can provide tolerance to subsequent injury. Several studies have documented that HSPs play an important role in the response of vascular cells to injury or stress. Whether the vasculature itself can be effectively preconditioned before arterial injury is unknown. Vascular HSP induction by whole-body hyperthermia (WBH) was evaluated with regard to its effects on the vascular response to balloon injury. WBH treatment of Sprague-Dawley rats (colonic temperatures of 41 to 42 degrees C for 15 minutes) resulted in maximal arterial HSP expression within 8 to 12 hours. Rats (male, 300 g, n=59) were randomly assigned to undergo either WBH or no treatment 8 hours before standard carotid balloon injury. At 14 (n=26) and 90 (n=21) days after balloon injury, histomorphometric analysis revealed a significant limitation of intimal accumulation in preconditioned arteries as compared to controls (intimal/medial area ratios+/-SEM: 14 days, 0.57+/-0.07 versus 0.86+/-0.08, P=0.01; 90 days, 0.78+/-0.12 versus 1.19+/-0.14, P<0.05). The medial cell proliferation index at...Continue Reading

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Citations

Mar 11, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zullyt Zamora RodríguezSiegfried Schulz
Mar 24, 2009·Irish Journal of Medical Science·P MagillK J Mulhall
Feb 27, 2004·Cardiovascular Radiation Medicine·Adam B LevittWolfgang Daum
Nov 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Qingbo XuKaushik Mandal
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Angelika Hammerer-LercherJohannes Mair
Jan 11, 2013·Autoimmune Diseases·Earl G Noble, Garry X Shen
Aug 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michiaki MatsumotoBojan Cercek

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