Thermal response in acute porcine malignant hyperthermia

Anesthesia and Analgesia
P A IaizzoD I Sessler

Abstract

This study was designed to evaluate how vital organ and skin-surface temperatures correlate with other clinical signs of a malignant hyperthermia (MH) episode. Six susceptible swine were anesthetized with thiopental and nitrous oxide and kept normothermic (approximately equal to 38 degrees C). After a 30-min control period, halothane (1 minimum alveolar anesthetic concentration) was administered, followed in 5 min by a bolus of succinylcholine (2 mg/kg intravenously). Monitoring included: 1) ETCO2; 2)PaO2, PaCO2, pHa; 3) cardiovascular function; 4) core temperatures (esophagus, pulmonary artery, and rectum); 5) organ temperatures (brain, kidney, liver, and four skeletal muscles); and 6) skin temperatures (forehead, neck, and axilla). Within 10 min after exposure to halothane and succinylcholine, all animals developed fulminant MH. Kidney, liver, and brain temperatures increased more rapidly than pulmonary artery temperature with the onset of MH. Temperatures significantly increased in the visceral organs prior to the detection of contractures within skeletal muscles. The masseter, longissimus dorsi, quadriceps, deltoid, and extensor digiti II intramuscular temperatures were 1-2 degrees C less than pulmonary artery and esophagea...Continue Reading

References

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Citations

Jul 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G Kozak-RibbensP J Cozzone
Dec 10, 2003·Best Practice & Research. Clinical Anaesthesiology·Syed Z AliHenry Rosenberg
Dec 10, 2003·Best Practice & Research. Clinical Anaesthesiology·Rainer Lenhardt
Aug 2, 2002·Clinical Neuropharmacology·Ronald J Gurrera
Feb 12, 2005·The Journal of Trauma·William P Bozeman, Ahamed H Idris
Jan 18, 2016·Lancet·Daniel I Sessler
Oct 1, 2011·Advances in Surgery·Nestor F Esnaola, David J Cole
May 31, 2007·AORN Journal·UNKNOWN AORN Recommended Practices Committee
Sep 29, 2001·Acta Anaesthesiologica Scandinavica·T i GardiH Ording
Aug 11, 2020·Anesthesiology·Daniel I Sessler
Nov 20, 1997·Anesthesiology·O PlattnerD Clough
Sep 13, 2012·Critical Care Research and Practice·Eric KipnisRonan Thibault

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