Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Dan NiLu-Yuan Lee

Abstract

A recent study has demonstrated that increasing the intrathoracic temperature from 36 degrees C to 41 degrees C induced a distinct stimulatory and sensitizing effect on vagal pulmonary C-fiber afferents in anesthetized rats (J Physiol 565: 295-308, 2005). We postulated that these responses are mediated through a direct activation of the temperature-sensitive transient receptor potential vanilloid (TRPV) receptors by hyperthermia. To test this hypothesis, we studied the effect of increasing temperature on pulmonary sensory neurons that were isolated from adult rat nodose/jugular ganglion and identified by retrograde labeling, using the whole cell perforated patch-clamping technique. Our results showed that increasing temperature from 23 degrees C (or 35 degrees C) to 41 degrees C in a ramp pattern evoked an inward current, which began to emerge after exceeding a threshold of approximately 34.4 degrees C and then increased sharply in amplitude as the temperature was further increased, reaching a peak current of 173 +/- 27 pA (n = 75) at 41 degrees C. The temperature coefficient, Q10, was 29.5 +/- 6.4 over the range of 35-41 degrees C. The peak inward current was only partially blocked by pretreatment with capsazepine (Delta I = 4...Continue Reading

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