Thermally activated state transition technique for femto-Newton-level force measurement

Optics Letters
Feng-Jung ChenLong Hsu

Abstract

We develop and test a thermally activated state transition technique for ultraweak force measurement. As a force sensor, the technique was demonstrated on a classical Brownian bead immersed in water and restrained by a bistable optical trap. A femto-Newton-level flow force imposed on this sensor was measured by monitoring changes in the transition rates of the bead hopping between two energy states. The treatment of thermal disturbances as a requirement instead of a limiting factor is the major feature of the technique, and provides a new strategy by which to measure other ultraweak forces beyond the thermal noise limit.

References

Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·R Zwanzig
Sep 22, 2001·Biophysical Journal·M K CheezumW H Guilford
May 9, 2003·Nature·Bryan T MarshallCheng Zhu
Mar 3, 2007·Annual Review of Biophysics and Biomolecular Structure·William J GreenleafSteven M Block
Mar 19, 2008·Optics Letters·F MuellerL J Wang
Sep 5, 2008·Nano Letters·O M MaragòA C Ferrari
Nov 28, 2005·Optics Express·Alexander Rohrbach
Apr 7, 2010·Physical Review Letters·Yih-Fan ChenJens-Christian Meiners
Jan 18, 2011·Journal of Bacteriology·Feng-Jung ChenLong Hsu

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