Thermo-controlled rheology of electro-assembled polyanionic polysaccharide (alginate) and polycationic thermo-sensitive polymers

Carbohydrate Polymers
Pape Momar NiangLuc Picton

Abstract

Several thermo-sensitive polyelectrolyte complexes were prepared by ionic self-association between an anionic polysaccharide (alginate) and a monocationic copolymer (polyether amine, Jeffamine®-M2005) with a 'Low Critical Solubility Temperature' (LCST). We show that electro-association must be established below the aggregation temperature of the free Jeffamine®, after which the organization of the system is controlled by the thermo-association of Jeffamine® that was previously electro-associated with the alginate. Evidence for this comes primarily from the rheology in the semi-dilute region. Electro- and thermo-associative behaviours are optimal at a pH corresponding to maximum ionization of both compounds (around pH 7). High ionic strength could prevent the electro-association. The reversibility of the transition is possible only at temperatures lower than the LCST of Jeffamine®. Similar behaviour has been obtained with carboxymethyl cellulose (CMC), which suggests that this behaviour can be observed using a range of anionic polyelectrolytes. In contrast, no specific properties have been found for pullulan, which is a neutral polysaccharide.

References

Jun 1, 1997·International Journal of Biological Macromolecules·I BatailleA Carpov
Apr 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Narayan BhattaraiMiqin Zhang
Jan 20, 1992·Biotechnology and Bioengineering·A MartinsenG Skjårk-Braek
Feb 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Damien L BerthierSébastien Lecommandoux
Mar 15, 2011·Journal of Colloid and Interface Science·Mohamed FettakaLuc Picton
Feb 2, 2013·International Journal of Pharmaceutics·Min ZhangKawthar Bouchemal
Apr 27, 2013·Carbohydrate Polymers·Sabrina BelbekhoucheLuc Picton

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Citations

Sep 17, 2016·Advances in Colloid and Interface Science·Yalin LiuSarah L Perry
Oct 22, 2020·BioMed Research International·Lili HeZhi-Xiang Yuan
Aug 29, 2019·ACS Omega·Alyssa ZerpaPedram Fatehi
Sep 25, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Gaihuan RenDejun Sun

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