Thermo-irreversible glycol chitosan/hyaluronic acid blend hydrogel for injectable tissue engineering.

Carbohydrate Polymers
Eun Joo LeeKang Moo Huh

Abstract

Thermogels that undergo temperature-dependent sol-gel transition have recently attracted attention as a promising biomaterial for injectable tissue engineering. However, conventional thermogels usually suffer from poor physical properties and low cell binding affinity, limiting their practical applications. Here, a simple approach for developing a new thermogel with enhanced physical properties and cell binding affinity is proposed. This thermogel (AcHA/HGC) was obtained by simple blending of a new class of polysaccharide-based thermogel, N-hexanoyl glycol chitosan (HGC), with a polysaccharide possessing good cell binding affinity, acetylated hyaluronic acid (AcHA). Gelation of AcHA/HGC was initially triggered by the thermosensitive response of HGC and gradually intensified by additional physical crosslinking mechanisms between HGC and AcHA, resulting in thermo-irreversible gelation. Compared to the thermos-reversible HGC hydrogel, the thermo-irreversible AcHA/HGC hydrogel exhibited enhanced physical stability, mechanical properties, cell binding affinity, and tissue compatibility. These results suggest that our thermo-irreversible hydrogel is a promising biomaterial for injectable tissue engineering.

Citations

Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alina SionkowskaJacek Piątek
Sep 19, 2020·International Journal of Molecular Sciences·Sathish Sundar Dhilip Kumar, Heidi Abrahamse
Sep 2, 2020·International Journal of Pharmaceutics·Natalia PettinelliFrancisca Lago
Feb 2, 2021·Colloids and Surfaces. B, Biointerfaces·Yin XiaoXiaoai He
Oct 21, 2020·International Journal of Biological Macromolecules·Ziyu GaoGiuseppe Tronci
Apr 30, 2021·Carbohydrate Polymers·Zhi-Yuan YaoJin-Song Shi
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Syed Ahmed ShahMubeen Kousar
Dec 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Lin WangQiang Wang
Oct 12, 2021·International Journal of Biological Macromolecules·Hamed NosratiMehdi Banitalebi-Dehkordi

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