Thermo-mechanical properties of poly ε-caprolactone/poly L-lactic acid blends: addition of nalidixic acid and polyethylene glycol additives

Journal of the Mechanical Behavior of Biomedical Materials
P DouglasG M Walker

Abstract

The search for ideal biomaterials is still on-going for tissue regeneration. In this study, blends of poly ε-caprolactone (PCL) with poly l-lactic acid (PLLA), nalidixic acid (NA) and polyethylene glycol (PEG) were prepared. Mechanical and thermal properties of the blends were investigated by tensile and flexural analysis, DSC, TGA, WXRD, MFI, BET, SEM and hot stage optical microscopy. Results showed that the loading of PLLA caused a significant decrease in tensile strength and almost total eradication of the elongation at break of PCL matrix, especially after PEG and NA addition. Increased stiffness was also noted with additional NA, PEG and PLLA, resulting in an increase in the flexural modulus of the blends. Isothermal degradation indicated that bulk PCL, PLLA and the blends were thermally stable at 200°C for the duration of 2h making extrusion of the blends at this temperature viable. Morphological study showed that increasing the PLLA content and addition of the very low viscosity PEG and powder NA decreased the Melt Flow Indexer and increased the viscosity. At the higher temperature, the PLLA begins to soften and eventually melts allowing for increased flow and, coupling this with, the natural increase in MFI caused by te...Continue Reading

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Citations

Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Thawatchai Phaechamud, Sasiprapa Chitrattha
Nov 23, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Sabrina Barbosa De Souza FerreiraMarcos Luciano Bruschi
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·S MontesantoV La Carrubba
Nov 14, 2020·Pharmaceutical Development and Technology·Camila Felix VecchiMarcos Luciano Bruschi
May 22, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Samuel SolomonAhmad B Albadarin

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