Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles

Journal of Controlled Release : Official Journal of the Controlled Release Society
Zheng ZhangJ Feijen

Abstract

Monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG(3)-PTMC(11), M(n) of mPEG=3.1 x 10(3) and M(n) of PTMC=10.8 x 10(3)g/mol) was synthesized by ring-opening polymerization of TMC using mPEG(3) as an initiator and stannous octoate as a catalyst. The block copolymer has a broad melting range with a peak at 49.5 degrees C and a heat of fusion of 47.6J/g. The heat of fusion normalized to the mPEG content is higher than that of the mPEG(3) polymer, suggesting that PTMC segments are also semi-crystalline. The mPEG(3)-PTMC(11) films were stable in water at room temperature, whereas at 37 degrees C the film specimens disintegrated and the amphiphilic block copolymer self-assembled into micellar-like nanoparticles with average sizes up to 210nm. The critical association concentration (CAC) of the formed micellar-like particles is 1.35 x 10(-3)mg/ml. The average size and polydispersity index of the formed mPEG(3)-PTMC(11) nanoparticles depend on temperature and storage time: the values decrease with increases in temperature and in storage time. By co-dissolving dexamethasone with mPEG(3)-PTMC(11) during the film preparation, micellar-like nanoparticles loaded with dexamethasone can be obtained after the film to mi...Continue Reading

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Citations

Aug 4, 2009·Expert Opinion on Drug Delivery·Xiuli Hu, Xiabin Jing
May 27, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZhiyuan Zhong
Apr 8, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Christophe FliedelSamuel Dagorne
Jun 15, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Uttam KedarVilasrao Kadam
Apr 18, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jieming GaoXingdong Zhang
Jun 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·C J F RijckenC F van Nostrum
Feb 17, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sara MovassaghianVladimir P Torchilin
Feb 1, 2012·New Journal of Chemistry = Nouveau Journal De Chimie·R Rajasekhar ReddyS Thayumanavan
Nov 2, 2017·Journal of Biomaterials Science. Polymer Edition·Yin LvRen-Xi Zhuo
Jul 31, 2020·Expert Opinion on Drug Metabolism & Toxicology·Vrinda GoteDhananjay Pal
Oct 2, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Charles SansonSébastien Lecommandoux

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