Thermo-triggered and biotinylated biotin-P(NIPAAm-co-HMAAm)-b-PMMA micelles for controlled drug release

Journal of Biomedical Materials Research. Part a
Cheng ChengRen-Xi Zhuo

Abstract

Thermosensitive and biotinylated biotin-poly (N-isopropylacrylamide-co-N-hydroxymethylacrylamide)-block-poly(methyl methacrylate) (biotin-P(NIPAAm-co-HMAAm)-b-PMMA) block copolymers were designed and synthesized. The conjugation of biotin molecule with the copolymer as well as the capability of easily functionalizing with ligands for pretargeting approach of the biotinylated multifunctional drug carrier was confirmed by a novel method called capillary electrophoresis immunoassay (CEIA) based on enhanced chemiluminescence (CL) detection. The biotin-P(NIPAAm-co-HMAAm)-b-PMMA copolymer was capable of self-assembling into nanometer-sized micelle. The anticancer drug methotrexate (MTX), used as a model drug, was loaded in the self-assembled micelles and the thermo-triggered release behavior of MTX was investigated.

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Citations

Jan 23, 2010·Journal of Materials Science. Materials in Medicine·Viji Mary VargheseT V Kumary
Sep 21, 2011·Nanomedicine·Marina Talelli, Wim E Hennink
Mar 7, 2013·Molecular Pharmaceutics·Eun Jung ChoYoon Yeo
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May 14, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aditi JhaveriVladimir Torchilin
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Xiaohui FanLingbing Li
Sep 8, 2011·International Journal of Pharmaceutics·Cong ChangRen-Xi Zhuo
Oct 10, 2015·Journal of Materials Science. Materials in Medicine·Yukun WuZhi Yuan
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Aug 1, 2017·Nature Reviews. Chemistry·Ashok KakkarRobert Langer
Feb 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·X-L SunA Pietrangelo
Oct 6, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Wen-Hsuan ChiangHsin-Cheng Chiu

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