Thermochemistry of non-covalent ion-molecule interactions

Mass Spectrometry
P B Armentrout, M T Rodgers

Abstract

The thermochemistry of non-covalent ion-molecule complexes has been examined by measuring quantitative bond dissociation energies using threshold collision-induced dissociation in guided ion beam tandem mass spectrometers (GIBMS). The methods used are briefly reviewed and several examples of the types of information and insight that can be obtained from such thermodynamic information are discussed. The hydration of metal cations, both singly and doubly charged, is reviewed and the trends elucidated, mainly on the basis of electrostatic contributions. The binding of alkali metal cations to amino acids has been examined for a range of systems, with both the overall polarizability of the amino acid and the local dipole moment of heteroatomic side-chains shown to be important contributors. The gas-phase interactions of the 12-crown-4 (12C4) polyether with alkali metal cations, classic molecular recognition systems in solution, have been newly compared to previous GIBMS work. These results validate the previous hypothesis that excited conformers were present for Rb(+)(12C4) and Cs(+)(12C4) and offer clues as to how and why they are formed.

References

Oct 1, 1987·Applied Biochemistry and Biotechnology·R J Linhardt
Sep 15, 2000·Mass Spectrometry Reviews·M T Rodgers, P B Armentrout
Dec 22, 2004·Accounts of Chemical Research·M T Rodgers, P B Armentrout
Jan 24, 2006·Journal of the American Chemical Society·S E Rodriguez-CruzE R Williams
Apr 13, 2007·Journal of Chemical Information and Modeling·Karen L SchuchardtTheresa L Windus
Jul 21, 2012·The Journal of Physical Chemistry. a·Theresa E Hofstetter, P B Armentrout

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Citations

Jul 26, 2013·Critical Reviews in Biochemistry and Molecular Biology·Sarah TrimpinEllen D Inutan
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bright D DanquahMichael O Glocker

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