Thermodynamic and kinetic characterization of polymorphic transformation of famotidine during grinding

International Journal of Pharmaceutics
Shan-Yang LinShun-Li Wang

Abstract

Two polymorphs of famotidine were prepared by recrystallization from acetonitrile for form A and methanol for form B, respectively. The effect of grinding process on the polymorphic transformation of famotidine was investigated. Each famotidine sample ground for various grinding times in a ceramic mortar was determined by differential scanning calorimetry (DSC), conventional and thermal Fourier transform infrared (FT-IR) microspectroscopy. The results indicate that the raw material of famotidine was proved to be a form B. A unique IR absorption band at 3505 cm(-1) for famotidine form B gradually decreased its intensity with the grinding time, while two newer IR absorption bands at 3451 and 1671 cm(-1) for famotidine form A slowly appeared. The peak intensity ratio of 3451/350 5 cm(-1) was linearly (r=0.9901) increased with the grinding time, suggesting that the grinding process could induce the polymorphic transformation of famotidine from form B to form A by a zero-order process. The DSC endothermic peaks also confirmed this polymorphic transformation from famotidine form B (167 degrees C, DeltaH: 165J/g) to famotidine form A (174 degrees C, DeltaH: 148J/g) in which the values of enthalpy were linearly reduced with the increas...Continue Reading

References

Jan 1, 1989·Journal of Pharmaceutical and Biomedical Analysis·B HegedüsL Párkányi
Feb 11, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·E YonemochiK Yamamoto
Apr 28, 2001·Advanced Drug Delivery Reviews·D E Bugay
Aug 23, 2002·Journal of Pharmaceutical and Biomedical Analysis·P MuraG P Bettinetti
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sherry L MorissetteOrn Almarsson
Oct 14, 2003·Drug Discovery Today·Ann W Newman, Stephen R Byrn
Mar 6, 2004·Pharmaceutical Development and Technology·Norbert Rasenack, Bernd W Müller
Sep 1, 2004·International Journal of Pharmaceutics·M MirmehrabiB Radatus
Dec 22, 2004·Annals of Clinical Microbiology and Antimicrobials·Devendra BansalNancy Malla

❮ Previous
Next ❯

Citations

Apr 24, 2014·Journal of Pharmaceutical Sciences·Pól MacfhionnghaileAndrea Erxleben
Jul 17, 2015·Journal of Pharmaceutical Sciences·Jinish PatelSarsvatkumar Patel
Jan 30, 2008·Journal of Pharmaceutical Sciences·Harry G Brittain
Nov 22, 2014·Pharmaceutical Development and Technology·Qi ZhangXuefeng Mei
Jan 16, 2013·International Journal of Pharmaceutics·Raitis BobrovsAndris Actiņš
Jan 18, 2011·Journal of Pharmaceutical and Biomedical Analysis·Norman ChiengJaakko Aaltonen
Jul 14, 2010·Journal of Pharmaceutical and Biomedical Analysis·Shan-Yang LinMing-Thau Sheu
Jun 22, 2010·International Journal of Pharmaceutics·Shan-Yang LinWen-Ting Ke
Oct 25, 2016·Journal of Pharmaceutical Sciences·M Teresa ViciosaHermínio P Diogo
Feb 6, 2017·Journal of Microencapsulation·Mohamed MokhtarPatrice Hildgen
Oct 1, 2014·Faraday Discussions·William Jones, Mark D Eddleston
Aug 23, 2021·International Journal of Pharmaceutics·Rodrigo Soto, Michael Svärd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.