Thermodynamic characteristics of mixed monolayers of amphotericin B and cholesterol

Journal of Colloid and Interface Science
Jennifer Cannon SykoraVitaly Vodyanoy

Abstract

Surface-pressure (Pi) and surface-area isotherms as a function of surface area were measured for monolayers of amphotericin B (AmB) and cholesterol mixtures at the air/water interface at 10, 20, and 30 degrees C. When chloroform/methanol was used as a spreading solvent, the Pi-A isotherms of the mixed monolayers exhibited characteristic transitions from the gas to liquid-expanded, then liquid-condensed, and finally the solid state. The expanding effect in monolayers was accompanied by a large Pi-A hysteresis and a positive excess of free energy of mixing at high Pi. At low Pi, a condensing effect was observed with the most significant deviation from ideality occurring at a mole fraction of AmB (XAmB) of 0.67. Free energy calculations revealed a condensing effect at low Pi and an expanding effect at high Pi except at 30 degrees C, where a condensing effect was observed for XAmB around 0.33. In contrast, when 2-propanol/water was used as spreading solvent, the mixed monolayers at 20 degrees C exhibited Pi-A isotherms which obey van der Waals equation of state, with no visible transitions, low hysteresis, a condensing effect, and a negative free energy of mixing. The most stable monolayers were produced from mixtures of AmB and ch...Continue Reading

References

Oct 1, 1992·Antimicrobial Agents and Chemotherapy·J BarwiczI Gruda
Oct 20, 1988·Biochimica Et Biophysica Acta·M Saint-Pierre-ChazaletC M Gary-Bobo
Jul 3, 1967·Biochimica Et Biophysica Acta·F VilallongaM S Fernandez
Jun 5, 1993·Biochimica Et Biophysica Acta·A R Balakrishnan, K R Easwaran
Dec 5, 2003·Journal of Colloid and Interface Science·Jennifer Cannon SykoraVitaly Vodyanoy

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Citations

Jan 18, 2006·Journal of Colloid and Interface Science·Cesar A S AndradeCelso P de Melo
May 27, 2009·The Journal of Chemical Physics·John D McCoy, John G Curro
Sep 17, 2010·Colloids and Surfaces. B, Biointerfaces·Rajesh GuntupalliVitaly Vodyanoy
Aug 8, 2007·Chemistry and Physics of Lipids·Katarzyna Hac-WydroPatrycja Dynarowicz-Łatka
Oct 5, 2018·The Journal of Membrane Biology·Felipe de Sá RochaCésar Augusto Souza de Andrade
Sep 17, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Pinchu XavierPadmanabhan Viswanath
Feb 8, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Graciela A Borioli, Bruno Maggio

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