PMID: 11929242Apr 4, 2002Paper

Thermodynamic correlation analysis: hydration and perturbation sensitivity of RNA secondary structures

Journal of the American Chemical Society
Peter Strazewski

Abstract

The thermodynamic parameters DeltaH, DeltaS, T(m), and DeltaG of a total of 36 RNA strands, 22 tetralooped 22mers, and 14 heptalooped 25mers (same stem sequence) were analyzed with respect to enthalpy-entropy compensation (EEC). The EEC plots [DeltaH, DeltaS] were compared with collected literature data from protein and nucleic acid unfolding studies (3224 and 241 datapoints, respectively) which all proved to be remarkably linear. The similarity of the compensation slopes and intercepts for all compounds indicate that, irrespective of the chemical nature and stability of the folding solutes, the exothermicity DeltaH and entropic penalty T x DeltaS of folding are strongly dominated by the rearrangement and formation of hydration layers around the solutes, while it is well-known that the stability of folding results only from the difference (DeltaG) and ratio (T(m)) of both parameters. EEC plots [DeltaH, DeltaS] are presented in an extended context, as 3D plots [DeltaH, DeltaS, T(m)] allowing for a correct analytical description of the enthalpy-entropy relationship and for more practical interpretations of large amounts of thermodynamic data when replotted as [DeltaH, T(m)] or [DeltaG(T), T(m)]. The introduction of a variety of m...Continue Reading

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Apr 4, 2002·Journal of the American Chemical Society·Ewa Biała, Peter Strazewski

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Citations

May 31, 2011·Journal of Medicinal Chemistry·Philippe WolffDominique Y Burnouf
Mar 18, 2004·Oligonucleotides·Jean-Louis Mergny, Laurent Lacroix
Dec 21, 2012·Future Microbiology·Rebekka Steinmann, Petra Dersch
Oct 28, 2009·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Barbara SaccàChristof M Niemeyer
Jun 21, 2012·Biophysical Journal·Hannah S SteinertHarald Schwalbe
Feb 3, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jérôme QuérardLudovic Jullien
Jun 16, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Stefano MonariMarco Borsari
Feb 4, 2011·The Journal of Physical Chemistry. B·Karl F Freed
Aug 24, 2006·Journal of the American Chemical Society·A BourdoncleJ-L Mergny

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