PMID: 2492828Feb 28, 1989Paper

Thermodynamic efficiency of bacterial growth calculated from growth yield of Pseudomonas oxalaticus OX1 in the chemostat

Biochimica Et Biophysica Acta
M RutgersK van Dam

Abstract

In order to determine the thermodynamic efficiency of bacterial growth, Pseudomonas oxalaticus OX1 was grown in carbon-limited continuous cultures. 11 different carbon sources, ranging from oxalate (most oxidised component) to ethanol (most reduced component), were used as limiting substrate in these experiments. From the experimental yield values (expressed as C-mol dry weight produced per C-mol carbon substrate consumed) the thermodynamic efficiencies were calculated. On substrates more reduced than biomass (such as ethanol and glycerol) the thermodynamic efficiency of growth of P. oxalaticus was negative but it reached a maximum of 23 +/- 3% with substrates with a degree of reduction of 3 (citrate) and lower. The actual concentrations of the components involved were incorporated into the calculations but this affected the overall thermodynamic efficiency only to a small extent. This result strengthens the conclusion of Westerhoff et al. (Westerhoff, H.V., Hellingwerf, K.J. and Van Dam, K. (1983) Proc. Natl. Acad. Sci. 80, 305-309) that bacteria have been optimised towards a theoretical thermodynamic efficiency of 24%, corresponding with maximisation of growth rate at optimal efficiency, with highly oxidised substrates.

References

Dec 1, 1987·Cell Biophysics·H V WesterhoffR J Wanders
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H V WesterhoffK Van Dam

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Citations

Apr 4, 2007·Biodegradation·Zhiwen Yuan, Jeanne M VanBriesen
Sep 13, 2005·Biotechnology and Bioengineering·Jinghua Xiao, Jeanne M VanBriesen
Jul 19, 2008·Biotechnology and Bioengineering·A NarangD Ramkrishna
Nov 7, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yusuke Himeoka, Kunihiko Kaneko

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