Thermodynamic phase behaviour of indomethacin/PLGA formulations

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Anke PrudicGabriele Sadowski

Abstract

In the current study, the phase behaviour of indomethacin and poly(lactic-co-glycolic acid) (PLGA) formulations was investigated as a function of the molecular weight and the copolymer composition of PLGA. The formulations were prepared by ball milling, and the phase behaviour, comprised of the glass-transition temperature of the formulations and the solubility of indomethacin in PLGA, was measured using modulated differential scanning calorimetry (mDSC). The results determined that the solubility of indomethacin in PLGA at room temperature was very low and increased with a corresponding decrease in the molecular weight of PLGA. The copolymer composition of PLGA had a minor effect on the indomethacin solubility. The effect of PLGA's molecular weight and copolymer composition on the solubility of indomethacin could be modelled using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) with a high degree of accuracy when compared with the experimental data. The glass-transition temperatures had a negative deviation from the weighted mean of the glass-transition temperatures of the pure substances, which could be described by the Kwei-equation.

References

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May 30, 2014·Molecular Pharmaceutics·Anke PrudicGabriele Sadowski
Oct 9, 2014·Molecular Pharmaceutics·Anke PrudicGabriele Sadowski

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Citations

Feb 18, 2016·Journal of Pharmaceutical Sciences·Thomas ReschkeChristoph Held
Jul 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Raphael PausYuanhui Ji
Jun 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anke PrudicGabriele Sadowski
Mar 10, 2015·International Journal of Pharmaceutics·Raphael PausYuanhui Ji
Feb 27, 2015·Pharmaceutical Research·Yuanhui JiGabriele Sadowski
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian LuebbertGabriele Sadowski
Mar 23, 2019·Annual Review of Chemical and Biomolecular Engineering·Michael Fischlschweiger, Sabine Enders
Nov 21, 2020·Journal of Pharmaceutical Sciences·Federico KarpDiana A Estenoz
Mar 4, 2021·Molecular Pharmaceutics·Alex MathersMichal Fulem
Oct 20, 2018·Molecular Pharmaceutics·Christian LuebbertGabriele Sadowski
Jan 9, 2018·Molecular Pharmaceutics·Christian LuebbertGabriele Sadowski

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