Thermodynamic Presynthetic Considerations for Ring-Opening Polymerization

Biomacromolecules
Peter OlsénAnn-Christine Albertsson

Abstract

The need for polymers for high-end applications, coupled with the desire to mimic nature's macromolecular machinery fuels the development of innovative synthetic strategies every year. The recently acquired macromolecular-synthetic tools increase the precision and enable the synthesis of polymers with high control and low dispersity. However, regardless of the specificity, the polymerization behavior is highly dependent on the monomeric structure. This is particularly true for the ring-opening polymerization of lactones, in which the ring size and degree of substitution highly influence the polymer formation properties. In other words, there are two important factors to contemplate when considering the particular polymerization behavior of a specific monomer: catalytic specificity and thermodynamic equilibrium behavior. This perspective focuses on the latter and undertakes a holistic approach among the different lactones with regard to the equilibrium thermodynamic polymerization behavior and its relation to polymer synthesis. This is summarized in a monomeric overview diagram that acts as a presynthetic directional cursor for synthesizing highly specific macromolecules; the means by which monomer equilibrium conversion relates...Continue Reading

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Citations

May 4, 2017·Biomacromolecules·Annabelle WattsMarc A Hillmyer
Jun 22, 2018·PloS One·Mariacristina Gagliardi, Angelo Bifone
Oct 28, 2017·Chembiochem : a European Journal of Chemical Biology·Marie A F DelgoveStefaan M A De Wildeman
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Jul 31, 2019·Proceedings of the National Academy of Sciences of the United States of America·Moran Frenkel-PinterLoren Dean Williams
May 25, 2021·Macromolecular Rapid Communications·Xiao-Wei KanZi-Chen Li
Jul 1, 2021·Journal of the American Chemical Society·Arron C DeacyCharlotte K Williams
Oct 20, 2017·Chemical Reviews·Xiangyi ZhangRobert M Waymouth
Oct 24, 2018·Journal of the American Chemical Society·Sudheendran MavilaChristopher N Bowman
Oct 21, 2021·Macromolecular Rapid Communications·Naomi C PaxtonMaria A Woodruff

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