Thermodynamic stability explains the differential evolutionary dynamics of cytochrome b and COX I in mammals.

Journal of Molecular Evolution
Juan Carlos AledoManuel Ruíz-Camacho

Abstract

By using a combination of evolutionary and structural data from 231 species, we have addressed the relationship between evolution and structural features of cytochrome b and COX I, two mtDNA-encoded proteins. The interior of cytochrome b, in contrast to that of COX I, exhibits a remarkable tolerance to changes. The higher evolvability of cytochrome b contrasts with the lower rate of synonymous substitutions of its gene when compared to that of COX I, suggesting that the latter is subjected to a stronger purifying selection. We present evidences that the stability effect of mutations (ΔΔG) may be behind these differential behaviour.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W M BrownA C Wilson
May 1, 1990·Biochemistry·J L Popot, D M Engelman
Aug 5, 1987·Journal of Molecular Biology·S MillerC Chothia
Jul 1, 1996·Molecular Biology and Evolution·J P Bielawski, J R Gold
Aug 27, 1998·Molecular Biology and Evolution·A ReyesC Saccone
Mar 11, 2000·Molecular Biology and Evolution·C D BustamanteD L Hartl
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·M EilersP J Fleming
Aug 31, 2000·Annual Review of Biochemistry·J L Popot, D M Engelman
Mar 27, 2001·Molecular Biology and Evolution·T R SchmidtL I Grossman
May 1, 2001·Journal of Molecular Biology·L Mirny, E Shakhnovich
Jun 25, 2002·Journal of Molecular Biology·Raphael GueroisLuis Serrano
Jun 29, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Carlos Aledo
Feb 4, 2005·Molecular Biology and Evolution·Jianzhi Zhang, Xionglei He
Jun 28, 2005·Nucleic Acids Research·Joost SchymkowitzLuis Serrano
Apr 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jesse D BloomFrances H Arnold
Apr 19, 2006·Nature Reviews. Genetics·Csaba PálMartin J Lercher
Jun 20, 2006·Molecular Biology and Evolution·Jesse D BloomClaus O Wilke
Sep 1, 2006·Molecular Phylogenetics and Evolution·Gavin C ConantPeter F Stadler
Oct 6, 2006·American Journal of Physiology. Cell Physiology·Ana Navarro, Alberto Boveris
Feb 1, 2007·Molecular Biology and Evolution·Yeong-Shin LinWen-Hsiung Li
May 8, 2007·Journal of Molecular Biology·Nobuhiko TokurikiDan S Tawfik
Feb 21, 2008·BMC Evolutionary Biology·John J WelchLindell Bromham
Mar 13, 2008·Annual Review of Neuroscience·Salvatore DiMauro, Eric A Schon
Oct 10, 2008·Molecular Biology and Evolution·Mihai AlbuBrian Golding
Oct 22, 2008·Nucleic Acids Research·Florian KieferTorsten Schwede
Jan 10, 2009·Nature Protocols·Lorenza BordoliTorsten Schwede
Feb 24, 2009·Molecular Biology and Evolution·Gavin C Conant, Peter F Stadler
Apr 25, 2009·PLoS Computational Biology·Curt ScharfeRonald W Davis
Jul 15, 2009·Molecular Biology and Evolution·Eric A Franzosa, Yu Xia
Jul 21, 2009·Biochemical Society Transactions·Tobias WarneckeLaurence D Hurst
Sep 1, 2009·Trends in Genetics : TIG·Gavin C Conant
Sep 22, 2009·Current Opinion in Structural Biology·Nobuhiko Tokuriki, Dan S Tawfik
Nov 27, 2010·Aging Cell·Juan Carlos AledoJuan Antonio Pérez-Claros

❮ Previous
Next ❯

Citations

Nov 26, 2015·Scientific Reports·Juan C AledoFrancisco J Veredas
Jan 26, 2021·PLoS Genetics·Alexey D NeverovGeorgii A Bazykin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

PLoS Computational Biology
Macarena Toll-RieraJoshua B Plotkin
Proceedings of the National Academy of Sciences of the United States of America
Agnes Tóth-Petróczy, Dan S Tawfik
© 2022 Meta ULC. All rights reserved