PMID: 3172208Jul 5, 1988Paper

Thermodynamic study of the apomyoglobin structure

Journal of Molecular Biology
Y V GrikoV P Kutyshenko

Abstract

Sperm whale apomyoglobin has been studied thermodynamically in solutions with different pH and temperature by scanning microcalorimetry, viscosimetry, nuclear magnetic resonance and circular dichroism spectrometry, and by electrometric and calorimetric titration. It has been shown that apomyoglobin in solutions with pH close to neutral has a compact and unique spatial structure with an extended hydrophobic core. This structure is maximally stable at about 30 degrees C and breaks down reversibly both upon heating or cooling from this temperature. The process of breakdown of this structure is highly co-operative and can be regarded as a transition between two macroscopic states of protein, the native and denatured states. In contrast to the native state, which is specified by definite values of compactness and ellipticity, the compactness and ellipticity of the denatured state of apomyoglobin depend strongly on pH; with a decrease of pH below 4.0, these parameters gradually approach the values of the random coil.

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Related Concepts

Apomyoglobin
Apoproteins
Calorimetry
Circular Dichroism, Vibrational
Hydrogen-Ion Concentration
Myoglobin
In Vivo NMR Spectroscopy
Thermodynamics
Viscosity
Right Whale, North Atlantic

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