PMID: 11900519Mar 20, 2002Paper

Thermodynamics of DNA interactions from single molecule stretching experiments

Accounts of Chemical Research
Mark C WilliamsV A Bloomfield

Abstract

On the basis of our analysis of detailed measurements of the dependence of the overstretching transition of double-stranded DNA (dsDNA) on temperature, pH, and ionic strength, we have demonstrated that a model of force-induced melting accurately describes the thermodynamics of DNA overstretching. Measurements of this transition allow us to determine the stability of dsDNA and obtain information similar to that obtained in thermal melting studies. This single-molecule technique has the advantage that it can be used to measure DNA stability at any temperature. We discuss the use of this technique to study the nucleic acid chaperone activity of the HIV-1 nucleocapsid protein.

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Citations

Jan 31, 2004·Analytical Biochemistry·Aiguo WuErkang Wang
Mar 14, 2003·Journal of Molecular Biology·Kiran PantMark C Williams
Jul 20, 2002·Current Opinion in Structural Biology·Mark C Williams, Ioulia Rouzina
May 24, 2011·The Journal of Physical Chemistry. a·Alexander BalaeffDavid N Beratan
May 3, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Aleksandra MihailovicMegan E Nuñez
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Claudia DanilowiczMara Prentiss
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark C WilliamsMicah J McCauley
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Niklas BosaeusBengt Nordén
Jul 3, 2009·Physical Biology·Leila ShokriMark C Williams
Feb 2, 2006·Nucleic Acids Research·Margareta CruceanuMark C Williams
Oct 2, 2007·Nucleic Acids Research·Igor D VilfanNynke H Dekker
Nov 9, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Sarah Anne Harris
Aug 8, 2008·Journal of Virology·Kristen M Stewart-MaynardKarin Musier-Forsyth
May 2, 2009·The European Physical Journal. E, Soft Matter·H FuC T Lim
Mar 8, 2013·The Journal of Chemical Physics·Flavio RomanoArd A Louis
Dec 3, 2008·The Journal of Chemical Physics·Stephen WhitelamPhillip L Geissler
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark C WilliamsKarin Musier-Forsyth
Jun 26, 2010·Physics of Life Reviews·Kathy R ChaurasiyaMark C Williams
Mar 24, 2010·Analytical Biochemistry·Ekaterina ProtozanovaRudolf Gilmanshin
Aug 12, 2009·Biochimica Et Biophysica Acta·Senthil K PerumalStephen J Benkovic
Jun 21, 2008·Journal of Molecular Biology·Kiran PantMark C Williams
Sep 25, 2007·Biophysical Journal·Zhidong LiZhen-Gang Wang
Nov 6, 2007·Biophysical Journal·Stephen WhitelamPhillip L Geissler
Nov 25, 2014·Biophysical Journal·David Argudo, Prashant K Purohit
Apr 19, 2005·Biophysical Journal·Micah McCauleyMark C Williams
Mar 31, 2016·Biophysical Journal·Ali A AlmaqwashiMark C Williams
Oct 30, 2007·Journal of Molecular Biology·Micah J McCauleyMark C Williams
Nov 18, 2009·Biophysical Journal·Christoph KleimannDario Anselmetti
Jun 15, 2007·Biophysical Journal·Julia MorfillHermann E Gaub
Feb 2, 2011·Biophysical Journal·Boris P Belotserkovskii, Philip C Hanawalt

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