PMID: 8603086Mar 13, 1996Paper

Thermodynamics of transfer of cholesterol from gel to fluid phases of phospholipid bilayers

Biochimica Et Biophysica Acta
C H SpinkM Breed

Abstract

The partitioning of cholesterol between gel and fluid phases of model membrane bilayers has been studied by differential scanning calorimetry. The partition coefficients and thermodynamics of transfer between phases of dimyristoyl-, dipalmitoyl-, distearoyl- and diarachidoylphosphatidylcholines were determined using a regular solution model for the partitioning process. The partition coefficient, which is the ratio of cholesterol in fluid to gel phase lipid, varies from 2.3 to 8.4 as the acyl chain length increases from the C14 to the C20 bilayer and determined at the phase transition temperature. The enthalpies of transfer increase from -46 to +32 kcal/mol as the chain length increases, and there is a compensating increase in the entropy of transfer. The results are interpreted in terms of a disruption of gel phase lipid by the cholesterol, which for the thinner bilayers is increased because the cholesterol molecule spans across the two leafs of the bilayer. At bilayer thicknesses between 18 and 19 carbons, the cholesterol can fit into one-half of the gel phase bilayer, and the enthalpy becomes positive, suggesting less disruption in the gel phase relative to the thinner bilayers. The data support the interpretation that chole...Continue Reading

References

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Citations

Jan 5, 2007·Annual Review of Biophysics and Biomolecular Structure·Gerald W Feigenson
Jan 24, 2007·Chemistry and Physics of Lipids·Daniel Wüstner
May 6, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Christina MatsingouCostas Demetzos
Dec 4, 1996·Biochimica Et Biophysica Acta·S Bransburg-ZabaryM Gutman
Jun 1, 2005·Biophysical Journal·Alekos TsamaloukasHeiko Heerklotz
Jan 22, 2008·Soft Matter·Deborah L GaterRobert V Law
Aug 5, 1997·Chemical Reviews·Sharon M. K. Davidson, Steven L. Regen

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