Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice

Scientific Reports
Yun Hye KimHoon-Ki Sung

Abstract

Intermittent fasting (IF) is an effective dietary intervention to counteract obesity-associated metabolic abnormalities. Previously, we and others have highlighted white adipose tissue (WAT) browning as the main underlying mechanism of IF-mediated metabolic benefits. However, whether IF retains its efficacy in different models, such as genetically obese/diabetic animals, is unknown. Here, leptin-deficient ob/ob mice were subjected to 16 weeks of isocaloric IF, and comprehensive metabolic phenotyping was conducted to assess the metabolic effects of IF. Unlike our previous study, isocaloric IF-subjected ob/ob animals failed to exhibit reduced body weight gain, lower fat mass, or decreased liver lipid accumulation. Moreover, isocaloric IF did not result in increased thermogenesis nor induce WAT browning in ob/ob mice. These findings indicate that isocaloric IF may not be an effective approach for regulating body weight in ob/ob animals, posing the possible limitations of IF to treat obesity. However, despite the lack of improvement in insulin sensitivity, isocaloric IF-subjected ob/ob animals displayed improved glucose tolerance as well as higher postprandial insulin level, with elevated incretin expression, suggesting that isocal...Continue Reading

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Nov 30, 2019·Reviews in Endocrine & Metabolic Disorders·José María Moreno-Navarrete, José Manuel Fernandez-Real
May 23, 2020·Molecular and Cellular Endocrinology·Isabel ReinischAndreas Prokesch
Jul 20, 2021·Trends in Endocrinology and Metabolism : TEM·Kafi N EaleyHoon-Ki Sung

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
Assay
ELISA

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