Abstract
The reason for the thermal abnormality associated with some breast cancers is unclear. We previously reported that a thermographic abnormality is associated with tumor size and lymph node involvement. Despite this association, we were unable to demonstrate an independent association between an abnormal thermogram and survival. To expand our previous findings, we assessed patients undergoing liquid crystal (contact) thermography (LCT) to identify a basis for the thermal abnormality and its relationship to survival. We assessed 420 women with invasive ductal carcinoma (IDC) followed for a mean of 6.2 years. In a consecutive series of 181 patients from the overall group, vascularity was assessed using a Doppler ultrasound (US) and microvessel density (MVD) by immunohistochemical staining with Factor VIII-related antigen. The tumor proliferation rate was measured immunohistochemically using Ki-67 monoclonal antibody. An abnormal thermogram was found in 18.6% of patients with IDC. A significant association was demonstrated between an abnormal LCT and age, stage, lymph nodal status, size, grade, and estrogen receptor status. We found no association between a LCT abnormality and MVD or proliferation rate. There was a significant relat...Continue Reading
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