Thermography. Its relation to pathologic characteristics, vascularity, proliferation rate, and survival of patients with invasive ductal carcinoma of the breast

Cancer
E E SternsF W Saunders

Abstract

The reason for the thermal abnormality associated with some breast cancers is unclear. We previously reported that a thermographic abnormality is associated with tumor size and lymph node involvement. Despite this association, we were unable to demonstrate an independent association between an abnormal thermogram and survival. To expand our previous findings, we assessed patients undergoing liquid crystal (contact) thermography (LCT) to identify a basis for the thermal abnormality and its relationship to survival. We assessed 420 women with invasive ductal carcinoma (IDC) followed for a mean of 6.2 years. In a consecutive series of 181 patients from the overall group, vascularity was assessed using a Doppler ultrasound (US) and microvessel density (MVD) by immunohistochemical staining with Factor VIII-related antigen. The tumor proliferation rate was measured immunohistochemically using Ki-67 monoclonal antibody. An abnormal thermogram was found in 18.6% of patients with IDC. A significant association was demonstrated between an abnormal LCT and age, stage, lymph nodal status, size, grade, and estrogen receptor status. We found no association between a LCT abnormality and MVD or proliferation rate. There was a significant relat...Continue Reading

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Citations

Nov 24, 1998·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·K R Foster
Aug 29, 2006·Medical Engineering & Physics·D Giansanti, G Maccioni
Feb 28, 2002·Medical Hypotheses·Shui-yin Lo
Apr 23, 2009·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Daniele GiansantiPaola Bernhardt
Sep 11, 2002·Breast Cancer Research and Treatment·Shozo OhsumiHisashi Usuki
Jul 9, 2008·Endocrine Reviews·Marc Prentki, S R Murthy Madiraju

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