Thermolabile beta-2 macroglycoprotein (Hakata antigen) in liver disease: biochemical and immunohistochemical study

Clinica Chimica Acta; International Journal of Clinical Chemistry
T FukutomiH Nawata

Abstract

Thermolabile beta-2 macroglycoprotein is a novel serum protein that was detected by an autoantibody in sera of a Japanese woman with systemic lupus erythematosus. We developed an enzyme-linked immunosorbent assay for this glycoprotein and measured its serum levels in patients with chronic liver disease. There were significant correlations between serum levels of this glycoprotein and those of albumin and cholinesterase. The serum levels of TL beta 2MG decreased with increasing severity of cirrhosis. Immunohistochemical staining using monoclonal anti-thermolabile beta-2 macroglycoprotein antibody revealed positive staining in the cytoplasm of the hepatocytes. These data strongly suggested that hepatocyte may be one of the production sites of this glycoprotein. Measurement of serum levels of this glycoprotein was useful for evaluation of hepatic function in chronic liver disease.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Apr 14, 1978·Biochemical and Biophysical Research Communications·T KawasakiI Yamashina
Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·F M ZuyderhoudtP Hengeveld
Jan 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TsubouchiS Kawakami
Jan 1, 1988·Upsala Journal of Medical Sciences·C O KindmarkK Persson
Aug 13, 1985·Biochemistry·A L TarentinoT H Plummer
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C O Kindmark, C B Laurell
Jan 1, 1984·CRC Critical Reviews in Biochemistry·A L Schwartz

❮ Previous
Next ❯

Citations

Oct 9, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mitsushi TsujimuraYoshiaki Maeda
Dec 6, 2003·Molecular Biology of the Cell·John P T HigginsMatt van de Rijn
Sep 6, 2011·Glycobiology·Anna SwierzkoCzeslaw Lugowski
Jan 14, 2003·Annual Review of Immunology·Uffe HolmskovJens C Jensenius
Nov 17, 2004·Clinical and Experimental Immunology·A P M AtkinsonD C Kilpatrick
Nov 18, 2003·Clinical and Experimental Immunology·D C KilpatrickT L Holyoake
Sep 10, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Tea L LaursenUNKNOWN US Acute Liver Failure Study Group
Feb 11, 2015·Immunobiology·Mateusz MichalskiMaciej Cedzyński
May 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M AkaiwaN Hamasaki
Jul 8, 2020·Expert Review of Clinical Immunology·Fateme BabahaAsghar Aghamohammadi
Aug 8, 1998·The Journal of Biological Chemistry·R SugimotoN Hamasaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.