Thermomechanical transitions of egg-ceramide monolayers

Langmuir : the ACS Journal of Surfaces and Colloids
Elisa R CatapanoIván López-Montero

Abstract

Ceramides have unique biophysical properties. Their high melting temperature and their ability to form lateral domains have converted ceramides into the paradigm of rigid lipids. Here, using shear surface rheology of egg-ceramide Langmuir monolayers, a solid to fluid transition was evidenced as a vanishing shear rigidity at lower temperatures than the lipid melting temperature. Such a mechanical transition, which depends on the lipid lateral pressure, was found in a broad range temperature (40-50 °C). The solid to fluid transition was correlated to a LC to LC+LE phase transition, as confirmed by BAM experiments. Interestingly, together with the softening transition, a supercooling process compatible with a glassy behavior was found upon freezing. A new phase scenario is then depicted that broadens the mechanical behavior of natural ceramides. The phase diversity of ceramides might have important implications in their physiological roles.

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Citations

Nov 13, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Agnieszka Olżyńska, Lukasz Cwiklik
Apr 6, 2018·Annual Review of Biophysics·Alicia Alonso, Félix M Goñi
Aug 22, 2017·Biophysics Reviews·María Laura Fanani, Bruno Maggio

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