Thermoregulation around a new set-point' established in the monkey by altering the ratio of sodium to calcium ions within the hypothalamus

The Journal of Physiology
R D Myers, Tony L Yaksh


1. The cerebral ventricles of the unanaesthetized monkey were perfused at a rate of 50-100 mul./min with artificial cerebrospinal fluid (c.s.f.) containing 11.0-34.0 mM excess sodium or 23.9-47.9 mM excess calcium ions. By repeated perfusions, a marked hyperthermia elicited by excess sodium or deep hypothermia by excess calcium was sustained for up to half a day.2. During the sodium-induced hyperthermia or calcium-induced hypothermia, the monkey thermoregulated adequately around the new level of temperature in response to either 50 or 150 ml. water heated to 58 degrees C or chilled to 0 degrees C and given by the intragastric route. Cold water produced a transient hypothermia after which temperature returned to the pre-load level; hot water given in the same way evoked a short-lasting hyperthermia, and again the temperature returned just to the new setpoint level.3. Perfusions at 50 mul./min of isolated areas of the diencephalon by means of push-pull cannulae with a solution containing 11.0-34.0 mM excess sodium ions or 11.3-47.9 mM excess calcium ions altered the body temperature of the monkey only when the sites of perfusion were located in the mammillary region of the posterior hypothalamus. Following the prolonged hyperther...Continue Reading


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