Thermoresponsive Epitope Surface-Imprinted Nanoparticles for Specific Capture and Release of Target Protein from Human Plasma

ACS Applied Materials & Interfaces
Senwu LiYukui Zhang

Abstract

Among various artificial antibodies, epitope imprinted polymer has been paid increasingly attention. To modulate the "adsorption and release" behavior by environment stimuli, N-isopropylacrylamide, was adopted to fabricate the thermoresponsive epitope imprinted sites. The prepared imprinted materials could adsorb 46.6 mg/g of target protein with the imprinting factor of 4.0. The template utilization efficiency could reach as high as 8.21%. More importantly, in the real sample, the materials could controllably capture the target protein from the human plasma at 45 °C and release it at 4 °C, which demonstrated the "on-demand" application potentials of such materials in the biomolecule recognition field.

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Citations

Apr 20, 2017·Sensors·Yeşeren SaylanAdil Denizli
Apr 11, 2021·Bioelectrochemistry·Tabkrich KhumsapLoc Thai Nguyen
Apr 17, 2021·Analytical Methods : Advancing Methods and Applications·Xindi WangQiong Jia
Jun 1, 2021·Chembiochem : a European Journal of Chemical Biology·Yan Zhao
Feb 14, 2019·ACS Applied Materials & Interfaces·Jingjing XuBernadette Tse Sum Bui
Jan 5, 2021·Journal of the American Chemical Society·Xiaowei LiYan Zhao
Nov 6, 2018·ACS Applied Materials & Interfaces·Mahalia A C SerranoRichard W Vachet
Jan 15, 2022·Chemical Communications : Chem Comm·Kaiqian Chen, Yan Zhao

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