Thermoresponsive gel for sustained release of BMP4 to inhibit corneal neovascularization.

Colloids and Surfaces. B, Biointerfaces
Lifeng XuXuejun Cui

Abstract

This work aimed to seek a sustained drug release system based on poloxamer-based thermoresponsive gel for sustained release drugs to inhibit corneal neovascularization (CNV) after eye operations. Thus, we designed and prepared a thermoresponsive gel with a phase transition temperature from 22 °C to 25 °C. When the concentrations of poloxamer (P) was 18% (w/w) and ε-Polylysine (EPL) was 0.5 mg/mL (P-18-EPL-05) in the thermoresponsive gel solution, the obtained thermoresponsive gel showed a suitable viscosity and strength in physiological condition. The viscosity, storage modulus G' and loss modulus G" of P-18-EPL-05 were 8 × 102 mPa.s, 1.17 × 104 Pa and 3.77 × 103 Pa, respectively. In-vitro release studies indicated that the drug release ratio of P-18-EPL-05 gel better than that of the poloxamer solution alone. The animal experiments indicated that the thermoresponsive gel loading bone morphogenetic protein 4 (BMP4) was better to inhibit CNV than the common solvent one. Overall, these results demonstrated that P-18-EPL-05 gel would be a promising platform as drug sustained systems for inhibiting CNV after eye injury in ophthalmic applications.

References

Jun 28, 2002·International Journal of Pharmaceutics·A H El-Kamel
Oct 6, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·HongBo YinZhiYong Qian
Feb 22, 2011·International Journal of Pharmaceutics·Tofeeq Ur-RehmanGerhard Gröbner
Jul 20, 2011·Journal of the American Chemical Society·Halil TekinAli Khademhosseini
Apr 14, 2012·Biomaterials·Zhiping ZhangSi-Shen Feng
Jan 26, 2013·Progress in Retinal and Eye Research·Felix BockClaus Cursiefen
Apr 16, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Terence Ta, Tyrone M Porter
Dec 18, 2013·Cytokine & Growth Factor Reviews·Prakash VempatiFeilim Mac Gabhann
Jul 7, 2015·Progress in Retinal and Eye Research·Keith M Meek, Carlo Knupp
Dec 18, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Mariana Volpato JunqueiraMarcos Luciano Bruschi
Dec 19, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marialaura AmadioAlessia Pascale
Feb 7, 2017·Chemical Society Reviews·Nane VanparijsBruno G De Geest
Apr 10, 2017·International Journal of Biological Macromolecules·Mitali DewanDipankar Chattopadhyay
Jan 10, 2018·Molecular Pharmaceutics·Maria A GrimaudoSara Nicoli
Jul 7, 2018·ACS Nano·Moien AlizadehgiashiEugenia Kumacheva
Jun 23, 2019·Experimental Eye Research·Inés Luis de RedínJuan M Irache

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.