Thermoresponsive hydrogels physically crosslinked with magnetically modified LAPONITE® nanoparticles

Soft Matter
Olena GoncharukIgor Mamyshev

Abstract

Recently, considering the potential applications of hydrogel nanocomposites in biomedical engineering, there has been a growing interest in the synthesis of hydrogels with improved mechanical properties. Among magnetic materials, iron oxides are of particular interest due to their magnetic properties and biocompatibility. At the same time, LAPONITE®, a synthetic clay, can be used to improve the mechanical properties of polymer-based nanocomposites. In this study we report the effects of hydrogel composition and structure on its thermoresponsive properties and hydrogel sorption and release of a model anticancer drug - 5-fluorouracil. Using one-step coprecipitation method we synthesized magnetic LAPONITE® (LAM) nanoparticles with magnetite-to-LAPONITE® weight ratios from 2 : 1 to 1 : 8. With increase in magnetite concentration the ferrofluidic properties of LAM nanoparticles are getting improved, while fluorouracil absorptivity - decreases. Exfoliation of the clay is observed when the magnetite content exceeds the LAPONITE® content. Physical crosslinking of poly(N-isopropylacrylamide) with LAM nanoparticles yields magnetic thermosensitive hydrogel nanocomposites with controllable temperature-induced drug release. All hydrogel nan...Continue Reading

References

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Citations

Feb 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyun ZhaiWilliam Weijia Lu

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Methods Mentioned

BETA
differential scanning calorimetry
X-ray
Scanning

Software Mentioned

MarvinSketch
Origin
OriginPro
LAPONITE®
Excel
Kernosenko
ChemAxon

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