Thermoreversible gel formulation containing sodium lauryl sulfate as a potential contraceptive device

Biology of Reproduction
C HaineaultM G Bergeron

Abstract

The contraceptive properties of a gel formulation containing sodium lauryl sulfate were investigated in both in vitro and in vivo models. Results showed that sodium lauryl sulfate inhibited, in a concentration-dependent manner, the activity of sheep testicular hyaluronidase. Sodium lauryl sulfate also completely inhibited human sperm motility as evaluated by the 30-sec Sander-Cramer test. The acid-buffering capacity of gel formulations containing sodium lauryl sulfate increased with the molarity of the citrate buffers used for their preparations. Furthermore, experiments in which semen was mixed with undiluted gel formulations in different proportions confirmed their physiologically relevant buffering capacity. Intravaginal application of the gel formulation containing sodium lauryl sulfate to rabbits before their artificial insemination with freshly ejaculated semen completely prevented egg fertilization. The gel formulation containing sodium lauryl sulfate was fully compatible with nonlubricated latex condoms. Taken together, these results suggest that the gel formulation containing sodium lauryl sulfate could represent a potential candidate for use as a topical vaginal spermicidal formulation to provide fertility control in ...Continue Reading

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Citations

Mar 12, 2013·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Amira ZaïriKhaled Hani
Aug 8, 2012·Drug Development and Industrial Pharmacy·Shaikh Karimunnisa, Pawar Atmaram
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Feb 16, 2019·Recent Patents on Drug Delivery & Formulation·Zeenat Iqbal, Fahima Dilnawaz

Methods Mentioned

BETA
xenografts

Related Concepts

Ampholytes
Drug Formulation Process
Gel
Wydase
Hydrogen-Ion Concentration
Dall Sheep
Irium
Sperm Motility
Vaginal Spermicides
Y-Chromosome-Bearing Sperm

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