Thermoreversible hydrogel scaffolds for articular cartilage engineering

Journal of Biomedical Materials Research. Part a
John P FisherA Hari Reddi

Abstract

Articular cartilage has limited potential for repair. Current clinical treatments for articular cartilage damage often result in fibrocartilage and are associated with joint pain and stiffness. To address these concerns, researchers have turned to the engineering of cartilage grafts. Tissue engineering, an emerging field for the functional restoration of articular cartilage and other tissues, is based on the utilization of morphogens, scaffolds, and responding progenitor/stem cells. Because articular cartilage is a water-laden tissue and contains within its matrix hydrophilic proteoglycans, an engineered cartilage graft may be based on synthetic hydrogels to mimic these properties. To this end, we have developed a polymer system based on the hydrophilic copolymer poly(propylene fumarate-co-ethylene glycol) [P(PF-co-EG)]. Solutions of this polymer are liquid below 25 degrees C and gel above 35 degrees C, allowing an aqueous solution containing cells at room temperature to form a hydrogel with encapsulated cells at physiological body temperature. The objective of this work was to determine the effects of the hydrogel components on the phenotype of encapsulated chondrocytes. Bovine articular chondrocytes were used as an experiment...Continue Reading

References

Jan 1, 1989·Connective Tissue Research·J F GuoD K MacCallum
Jan 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·J GlowackiJ Folkman
Aug 3, 2001·Journal of Biomedical Materials Research·G MirallesE Payan
Oct 18, 2001·Clinical Orthopaedics and Related Research·L LuM J Yaszemski
Jun 26, 2002·Annals of the New York Academy of Sciences·J H ElisseeffY Yamada
Sep 10, 2002·Clinical Orthopaedics and Related Research·J A Buckwalter
Jan 25, 2003·Tissue Engineering·Marcy WongDaniel Studer
Sep 2, 2003·Nature Biotechnology·Misako Nakashima, A Hari Reddi
Jun 9, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Madhura D GoleIsrael Ziv

❮ Previous
Next ❯

Citations

Aug 13, 2011·Journal of Materials Science. Materials in Medicine·Mohammad Kazem GhahramanpoorMohamadreza Baghaban Eslaminejad
Jun 7, 2005·Cytokine & Growth Factor Reviews·Howard Seeherman, John M Wozney
Jun 2, 2012·Nature Protocols·Lucas A KinardAntonios G Mikos
May 6, 2006·Tissue Engineering·Jerry C Hu, Kyriacos A Athanasiou
Jul 30, 2010·Tissue Engineering. Part a·Yihong GongDong-An Wang
May 24, 2008·Tissue Engineering. Part B, Reviews·Garret D Nicodemus, Stephanie J Bryant
Sep 15, 2010·Tissue Engineering. Part B, Reviews·José BecerraA Hari Reddi
May 21, 2011·Tissue Engineering. Part B, Reviews·A Hari ReddiJosé A Andrades
Aug 20, 2010·Journal of the Royal Society, Interface·Kangwon LeeDavid J Mooney
Apr 23, 2008·Pediatric Research·Minal Patel, John P Fisher
Oct 19, 2011·Journal of Biomedicine & Biotechnology·Seogjin Seo, Kun Na
Nov 28, 2015·International Journal of Molecular Sciences·Michael C Hacker, Hafiz Awais Nawaz
Nov 3, 2007·Advanced Drug Delivery Reviews·Cindy Chung, Jason A Burdick
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leda Klouda, Antonios G Mikos
May 18, 2007·Advanced Drug Delivery Reviews·James D KretlowAntonios G Mikos
May 15, 2007·Advanced Drug Delivery Reviews·Eduardo K MoioliJeremy J Mao
May 15, 2007·Advanced Drug Delivery Reviews·Soo-Hong Lee, Heungsoo Shin
Nov 28, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·S ToegelM Wirth
Oct 4, 2005·Journal of Neuroscience Methods·Niraj J MuniDavid R Pepperberg
Jan 11, 2013·Journal of Tissue Engineering and Regenerative Medicine·Elena G PopaManuela E Gomes
Oct 26, 2005·Osteoarthritis and Cartilage·A Kangarlu, H K Gahunia
Feb 6, 2007·Biochemical and Biophysical Research Communications·Maria BokhariStefan A Przyborski
Mar 20, 2018·International Journal of Biomaterials·Magdalini TsintouAlexander Seifalian
Oct 7, 2014·Macromolecular Bioscience·Nandana BhardwajBiman B Mandal
Dec 30, 2006·Macromolecular Bioscience·Joerg K Tessmar, Achim M Göpferich
Aug 19, 2007·Journal of Biomedical Materials Research. Part a·Mingbo WangJ A Jansen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.