Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model

Scientific Reports
Qinjie WuChangyang Gong

Abstract

Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, which combined the anti-adhesion barrier with controlled release of anti-adhesion drug. Dexamethasone (Dex) was encapsulated in polymeric micelles (Dex micelles), and then the Dex micelles were loaded into biodegradable and thermosensitive hydrogel. The obtained Dex hydrogel showed a temperature-dependent sol-gel-sol phase transition behavior. The Dex hydrogel could form a non-flowing gel in situ upon subcutaneous injection and gradually degrade in about 20 days. In addition, Dex hydrogel was assigned for anti-adhesion studies in a more rigorous recurrent adhesion animal model. Compared with normal saline (NS) and Dex micelles group, tissue adhesions in hydrogel and Dex hydrogel group were significantly alleviated. In Dex hydrogel group, the media adhesion score is 0, which was dramatically lower than that in blank hydrogel group (2.50, P < 0.001). In histopathological examination and scanning electron microscopy (SEM) analysis, an integral neo-mesothelial cell layer with microvilli on their surface was observed, which revealed that the injured parieta...Continue Reading

References

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Citations

Aug 28, 2019·Pharmaceutics·Anca OnaciuIoana Berindan-Neagoe
Jul 4, 2018·Scientific Reports·Alice Rita SalgarellaLeonardo Ricotti
Apr 4, 2019·International Journal of Molecular Sciences·Shih-Heng ChenFeng-Huei Lin
Sep 25, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yang DengW Mark Saltzman
Dec 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ershuai ZhangZhiqiang Cao
Jan 16, 2021·Advanced Healthcare Materials·Anna Zahoranová, Robert Luxenhofer
Jan 20, 2021·Macromolecular Bioscience·Arvind K Singh ChandelTaichi Ito
Dec 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yun-Chu ChenYoon Yeo
Mar 13, 2021·Advanced Functional Materials·Ershuai ZhangZhiqiang Cao

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Methods Mentioned

BETA
dissection
scanning electron microscopy
light microscopy

Software Mentioned

SPSS

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