Thermosensitive hydrogel of hydrophobically-modified methylcellulose for intravaginal drug delivery.

Journal of Materials Science. Materials in Medicine
Ning LiAnjie Dong

Abstract

Hydrogels with the advantages of prolonging drug release and administration convenience are necessary for intravaginal drug delivery to prevent sexual transmission of human immunodeficiency virus and other vaginal infections. In this study, the thermosensitive hydrogel of methylcellulose modified by stearic acid (MCS) were evaluated in the presence of NaCl and phosphates, which exhibited sol-to-gel transition performance at body temperature or even lower. The in vitro cytotoxicity and in vivo mucosal irritation were investigated and the results showed that MCS hydrogel possessed good biocompatibility similar with hydroxyethyl cellulose (HEC) gel. Significantly, the release studies revealed that MCS hydrogel could control tenofovir sustained release for 10 h without burst release, longer than that from HEC gel or poloxamer 407 hydrogel. Therefore, MCS thermosensitive hydrogel would be a promising carrier for intravaginal delivery of antiviral drugs for long time controlled release.

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Citations

Mar 26, 2013·Journal of Materials Science. Materials in Medicine·Ya Nan WeiXi Guang Chen
Nov 4, 2016·Drug Delivery and Translational Research·Marion JamardHeather Sheardown
Nov 4, 2017·Journal of Drug Targeting·Sebastien TaurinMargit M Janát-Amsbury
Apr 11, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Wenxue TianYong Sun
Aug 5, 2020·Drug Delivery and Translational Research·Malobika Chakravarty, Amisha Vora
Nov 26, 2020·Materials·Diana Elena CiolacuFlorin Ciolacu
Oct 30, 2020·Tissue Engineering. Part B, Reviews·Lorenzo BonettiSilvia Farè

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