Thermosensitive hydrogels a versatile concept adapted to vaginal drug delivery

Journal of Drug Targeting
Sebastien TaurinMargit M Janát-Amsbury

Abstract

Vaginal drug delivery represents an attractive strategy for local and systemic delivery of drugs otherwise poorly absorbed after oral administration. The rather dense vascular network, mucus permeability and the physiological phenomenon of the uterine first-pass effect can all be exploited for therapeutic benefit. However, several physiological factors such as an acidic pH, constant secretion, and turnover of mucus as well as varying thickness of the vaginal epithelium can impact sustained drug delivery. In recent years, polymers have been designed to tackle challenges mentioned above. In particular, thermosensitive hydrogels hold great promise due to their stability, biocompatibility, adhesion properties and adjustable drug release kinetics. Here, we discuss the physiological and anatomical uniqueness of the vaginal environment and how it impacts the safe and efficient vaginal delivery and also reviewed several thermosensitive hydrogels deemed suitable for vaginal drug delivery by addressing specific characteristics, which are essential to engage the vaginal environment successfully.

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Citations

Sep 4, 2018·Journal of Drug Targeting·Li LiDong-Gang Xu
Dec 15, 2019·Pharmaceutics·Eleonora Russo, Carla Villa
Jan 23, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Débora Fretes ArgentaThiago Caon
Dec 10, 2020·The Journal of Sexual Medicine·Carlos Campagnaro M Dos SantosMaria Inês Da Rosa

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