Thermosensitive hydrogels as a controlled release system for alkannin to improve localized treatment of Candida vaginitis after external beam radiotherapy in vitro and in vivo

Pathogens and Disease
Jin SuJiye Zhang

Abstract

External beam radiotherapy increases the risk of Candida vaginitis in cervical cancer patients, which brings a lot of insufferable influence to their life. Here, we explored the efficacy of alkannin in the treatment of Candida vaginitis after external beam radiotherapy. We exploit thermosensitive hydrogel-mediated alkannin as the topical formulation in a rat model established in our work. Periodic acid-Schiff of vaginas indicated little Candida albicans adhered to the vaginal tissue in treatment group. Additionally, hematoxylin and eosin stain revealed that inflammatory response of high dose alkannin was reduced. Above all, the animal model was first established in our work for the clinical desire. Our results suggested the promising application of alkannin for the disease with satisfying fungicidal activity and anti-inflammatory activity.

References

Jan 1, 1988·Gynecologic Oncology·J A StrykerJ Shafer
Jun 20, 1998·Clinical Microbiology Reviews·T C WhiteR A Bowden
Oct 31, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·K EdsmanR Petersson
Jun 28, 2002·International Journal of Pharmaceutics·Jung Yun ChangChong-Kook Kim
Jul 3, 2009·The Journal of Antimicrobial Chemotherapy·Gloria M GonzálezMariana Elizondo
Jul 29, 2009·Antimicrobial Agents and Chemotherapy·Gloria M GonzálezJ Gerardo González
Apr 13, 2010·Microbial Pathogenesis·Arianna TavantiSonia Senesi
Feb 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Petra GeorgWolfgang Dörr
Apr 5, 2012·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·El-Sayed Ali IbrahimNoura Hassan Abdellah
Nov 6, 2012·Biological & Pharmaceutical Bulletin·Hao MiaoYingYing Cao
Sep 28, 2013·Revista iberoamericana de micología·Mariana Elizondo-ZertucheGloria M González
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
May 17, 2017·Advanced Pharmaceutical Bulletin·Mitra Alami-MilaniMitra Jelvehgari
Oct 8, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Franklin C KenechukwuPaul A Akpa
Oct 25, 2017·Frontiers in Microbiology·Julien ChaillotAdnane Sellam
Feb 1, 1999·Angewandte Chemie·Vassilios P PapageorgiouK C Nicolaou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.