Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Zheyu ShenJinpei Wan

Abstract

Thermosensitive Poly(N-isopropylacrylamide-co-acrylamide-co-allylamine) (PNIPAM-AAm-AA)-conjugated albumin nanospheres (PAN) was developed as a new thermal targeting anti-cancer drug carrier by conjugating PNIPAM-AAm-AA on the surface of albumin nanospheres (AN). AN with diameter below 200nm and narrow size distribution was successfully prepared in the first step with desolvation technique. PNIPAM-AAm-AA with different molecular weight (M(w)) was synthesized in the second step by radical polymerization and conjugated onto the surface of AN. Anti-cancer drug adriamycin (ADR) was then entrapped into the AN and PAN during the particle preparation. Compared with AN, the release rate of ADR from PAN in trypsin solution was slower, and decreased with increasing the conjugation amounts (hairy density) or M(w) of PNIPAM-AAm-AA (hairy length). Moreover, the release of ADR from PAN above the cloud-point temperature (T(cp)) of PNIPAM-AAm-AA became faster due to shrinkage of hairy thermosensitive polymer. To testify the thermal targetability in vivo, PAN was incubated with HepG2 cells. As expected, PAN can target cancer cells above the T(cp) of PNIPAM-AAm-AA, whereas it cannot below the T(cp). These results might reflect that PAN may selec...Continue Reading

References

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·T InoueA S Hoffman
Aug 11, 1998·Nature·R A Siegel
Oct 28, 1999·International Journal of Pharmaceutics·W LinL Illum
Mar 4, 2000·Advances in Colloid and Interface Science·R Pelton
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J E ChungT Okano
Nov 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Hoon JeongTae Gwan Park
Oct 6, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Osamu SogaWim E Hennink
Mar 15, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Osamu SogaWim E Hennink
Jul 27, 2007·International Journal of Pharmaceutics·Zhe-Yu ShenZhi-Guo Su

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Citations

Aug 12, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·C AlexiouS Lyer
Nov 3, 2011·Chemical Communications : Chem Comm·Charlotte JamesA Toby A Jenkins
Jul 28, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dimitrios BikiarisEvangelos Karavas
Oct 6, 2012·Journal of Drug Targeting·Lakshmi Prasanna KolluruMartin J D'Souza
Dec 25, 2012·International Journal of Pharmaceutics·Xuhua LiangYingyong Zhao
Aug 16, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyNazik A Elgindy
Mar 6, 2012·Nanomedicine·Rainer TietzeChristoph Alexiou
Jul 30, 2015·Biomaterials Science·Shahdeep KaurRinti Banerjee
Sep 4, 2015·Soft Matter·Efe Armagan, Gozde Ozaydin Ince
Jun 24, 2017·Journal of Biomedical Materials Research. Part a·Swaroop ChakrabortySuperb K Misra
May 14, 2011·Macromolecular Rapid Communications·Klaus EiseleTanja Weil
Oct 21, 2011·Macromolecular Bioscience·Samer R AbulateefehCameron Alexander
Jul 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue-Hua MaAi-Guo Wu
Mar 8, 2016·Macromolecular Bioscience·Yanyan Jiang, Martina Stenzel
Feb 20, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Güliz AkSenay Hamarat Sanlɪer
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lu LuKaiyong Cai
Sep 25, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sjaikhurrizal El MuttaqienNobuhiro Nishiyama
Jul 3, 2021·Nanomaterials·Chi-Ling ChiangChih-Hsin Lin
Dec 4, 2010·Biomacromolecules·Prodip SarkerStephen Rimmer

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