Thermosensitive poly(organophosphazene) hydrogels for a controlled drug delivery

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Gyung Don KangSoo-Chang Song

Abstract

Thermosensitive poly(organophosphazenes) were synthesized for a controlled release of hydrophilic polymeric model drugs such as dextran and albumin in this study. The solutions of the present polymers bearing both hydrophobic side groups of L-isoleucine ethyl ester (IleOEt) and hydrophilic groups of alpha-amino-omega-methoxy-PEG (Mw 550) (AMPEG550) exhibited reversible sol-gel transition behaviors with changes of temperature. Viscometric measurement indicated that the thermosensitive hydrogels with good strength could be formed from the solutions in the range of the concentrations of 7-15 wt% around body temperature. For increasing their biodegradabililites, depsipeptides of ethyl-2-(O-glycyl)lactate (GlyLacOEt) were also introduced to the polymer, showing enhanced degradation of hydrogels. In vitro release behaviors of hydrophilic FITC-dextran (Mw 71,600) and human serum albumin from these polymer hydrogels were sustained for about 2 weeks while those from poloxamer (Pluronic F-127) hydrogel showed a distinct initial burst. The release of FITC-dextran exhibited concentration-dependent behavior ranging from 7 to 15 wt% of the polymer solution while it was almost independent of the concentration of FITC-dextran.

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Citations

Feb 29, 2008·Journal of Materials Science. Materials in Medicine·Baljit SinghNirmala Chauhan
May 2, 2009·Archives of Pharmacal Research·Ahmed M Al-AbdHyo-Jeong Kuh
May 13, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dan WangYouxin Li
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May 16, 2009·Expert Opinion on Therapeutic Patents·Xiao-Jie JuLiang-Yin Chu
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Oct 13, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed M Al-AbdHyo-Jeong Kuh
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