PMID: 31363206DOI: 10.1038/s41592-019-0498-4Aug 1, 2019Paper
Thesaurus: quantifying phosphopeptide positional isomers
Nature Methods
Brian C SearleJudit Villén
Abstract
Proteins can be phosphorylated at neighboring sites resulting in different functional states, and studying the regulation of these sites has been challenging. Here we present Thesaurus, a search engine that detects and quantifies phosphopeptide positional isomers from parallel reaction monitoring and data-independent acquisition mass spectrometry experiments. We apply Thesaurus to analyze phosphorylation events in the PI3K/AKT signaling pathway and show neighboring sites with distinct regulation.
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Citations
Dec 31, 2019·Molecular Systems Biology·Mario LeutertJudit Villén
Mar 28, 2020·Nature Communications·Brian C SearleMathias Wilhelm
Feb 9, 2020·Nature Communications·Dorte B Bekker-JensenJesper V Olsen
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Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Lindsay K PinoBrian C Searle
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Methods Mentioned
BETA
acetylation
Software Mentioned
Comet
Daily
PeptideProphet
EncyclopeDIA
PTMProphet
Thesaurus
Skyline
PyProphet
TraML
ReAdW
Related Concepts
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AKT Pathway
This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.
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