Theta frequency decreases throughout the hippocampal formation in a focal epilepsy model

Hippocampus
Antje KiliasUlrich Egert

Abstract

Mesial temporal lobe epilepsy is characterized by focal, recurrent spontaneous seizures, sclerosis and granule cell dispersion (GCD) in the hippocampal formation. Changes in theta rhythm properties have been correlated with the severity of hippocampal restructuring and were suggested as a cause of memory deficits accompanying epilepsy. For severe sclerosis, it has even been questioned whether theta band oscillations persist. We asked how theta oscillations change with graded restructuring along the longitudinal hippocampal axis and whether these changes correlate with the overall severity of temporal lobe epilepsy. We recorded local field potentials in the medial entorhinal cortex and along the septo-temporal axis of the dentate gyrus at sites with different degrees of GCD in freely behaving epileptic mice. Theta frequency was decreased at all recording positions throughout the dentate gyrus and in the medial entorhinal cortex, irrespective of the extent of GCD or the rate of severe epileptic events. The frequency reduction by up to 1.7 Hz, corresponding to 1/3 octaves within the theta range, was present during rest, exploration and running. Despite the frequency reduction, theta oscillations remained coherent across the hippoc...Continue Reading

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Citations

Jun 21, 2018·Journal of Neural Engineering·Antje KiliasPolina Anikeeva
Oct 13, 2019·The European Journal of Neuroscience·Laëtitia Chauvière
Jun 10, 2020·Canadian Journal of Physiology and Pharmacology·Hang XingXiong Han
Aug 14, 2021·Neuroscience and Biobehavioral Reviews·Esther PototskiyAlberto E Musto
Mar 13, 2020·ACS Applied Materials & Interfaces·Christian BoehlerMaria Asplund

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