Theta-frequency membrane resonance and its ionic mechanisms in rat subicular pyramidal neurons

Neuroscience
W-T WangS-J Hu

Abstract

The neuron population of the hippocampal formation exhibits oscillatory activity within the theta (theta) frequency band (4-10 Hz), and the intrinsic resonance properties of individual hippocampal neurons contribute to this network oscillation. The subiculum is the pivotal output region of the hippocampal formation and it is involved in many of the physiological and pathological functions of the limbic system. To study the characteristics and underlying mechanisms of resonance activity in subicular pyramidal neurons, we performed whole-cell patch-clamp recordings from these neurons in rat horizontal brain slices. We applied sinusoidal currents with constant amplitudes and linearly increasing frequencies to measure the resonance frequency of subicular pyramidal neurons. We found that the resonance frequency of subicular pyramidal neurons was about 2 Hz at room temperature and 4-6 Hz at 32-35 degrees C. The resonance frequency increased at hyperpolarized membrane potentials and decreased at depolarized membrane potentials. We also investigated three sub-threshold currents involved in the resonance: a slow hyperpolarization-activated cation current; an instantaneously activating, inwardly rectifying potassium current; and an inwar...Continue Reading

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Citations

Oct 2, 2008·Biological & Pharmaceutical Bulletin·Ruidong YeGang Zhao
Jan 28, 2014·PloS One·Jorge VeraMagdalena Sanhueza
May 22, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vahid Tohidi, Farzan Nadim
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Jun 29, 2021·Progress in Biophysics and Molecular Biology·Crescent L Combe, Sonia Gasparini

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