Theta oscillations decrease spike synchrony in the hippocampus and entorhinal cortex

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Kenji Mizuseki, G Buzsáki

Abstract

Oscillations and synchrony are often used synonymously. However, oscillatory mechanisms involving both excitation and inhibition can generate non-synchronous yet coordinated firing patterns. Using simultaneous recordings from multiple layers of the entorhinal-hippocampal loop, we found that coactivation of principal cell pairs (synchrony) was lowest during exploration and rapid-eye-movement (REM) sleep, associated with theta oscillations, and highest in slow wave sleep. Individual principal neurons had a wide range of theta phase preference. Thus, while theta oscillations reduce population synchrony, they nevertheless coordinate the phase (temporal) distribution of neurons. As a result, multiple cell assemblies can nest within the period of the theta cycle.

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Citations

Feb 27, 2014·Nature Reviews. Neuroscience·György Buzsáki, Kenji Mizuseki
Apr 22, 2014·Brain Research Bulletin·Jan KonopackiPaulina Kłos-Wojtczak
Jan 15, 2015·ACS Chemical Neuroscience·Bhagya GunasekeraLohitash Karumbaiah
Feb 11, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Bahar Güntekin, Erol Başar
Mar 5, 2016·Brain Research·Kei M Igarashi
Nov 4, 2016·Scientific Reports·Juliana CorlierMichel Le Van Quyen
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Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom HartleyJohn O'Keefe
Mar 10, 2017·Physiological Reviews·Mikhail A Lebedev, Miguel A L Nicolelis
Oct 13, 2019·The European Journal of Neuroscience·Laëtitia Chauvière
Nov 20, 2016·The Journal of Physiological Sciences : JPS·Takuma KitanishiTakatoshi Hikida
May 17, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Reimbay ReimbayevIgor Belykh
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Jul 22, 2020·Physical Review. E·Barrett N BristerIgor V Belykh
Oct 20, 2019·Behavioural Brain Research·Laetitia Chauvière

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