Theta phase precession of grid and place cell firing in open environments

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
A JeewajeeNeil Burgess

Abstract

Place and grid cells in the rodent hippocampal formation tend to fire spikes at successively earlier phases relative to the local field potential theta rhythm as the animal runs through the cell's firing field on a linear track. However, this 'phase precession' effect is less well characterized during foraging in two-dimensional open field environments. Here, we mapped runs through the firing fields onto a unit circle to pool data from multiple runs. We asked which of seven behavioural and physiological variables show the best circular-linear correlation with the theta phase of spikes from place cells in hippocampal area CA1 and from grid cells from superficial layers of medial entorhinal cortex. The best correlate was the distance to the firing field peak projected onto the animal's current running direction. This was significantly stronger than other correlates, such as instantaneous firing rate and time-in-field, but similar in strength to correlates with other measures of distance travelled through the firing field. Phase precession was stronger in place cells than grid cells overall, and robust phase precession was seen in traversals through firing field peripheries (although somewhat less than in traversals through the ce...Continue Reading

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Citations

Apr 4, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel Bush, Neil Burgess
Oct 7, 2014·Journal of Computational Neuroscience·Filippo Cona, Mauro Ursino
Apr 9, 2015·Frontiers in Systems Neuroscience·Lauren L LongJames J Chrobak
Feb 26, 2015·PLoS Computational Biology·Benjamin DunnYasser Roudi
Mar 27, 2018·The European Journal of Neuroscience·Karthik SomanVaddadi Srinivasa Chakravarthy
Aug 27, 2014·Hippocampus·Sandro Romani, Misha Tsodyks
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom HartleyJohn O'Keefe
Mar 20, 2015·Hippocampus·Michael E Hasselmo, Chantal E Stern
Nov 2, 2019·Hippocampus·Mauro M Monsalve-Mercado, Yasser Roudi
Mar 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·James P RoachMichal R Zochowski
Nov 30, 2019·Frontiers in Systems Neuroscience·James P RoachMichal R Zochowski
Jan 27, 2019·PLoS Computational Biology·Joseph D MonacoKechen Zhang
Feb 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Giulio CasaliKate Jeffery
Jul 3, 2019·Frontiers in Cellular Neuroscience·Céline Drieu, Michaël Zugaro
Feb 18, 2020·Hippocampus·Daniel Bush, Neil Burgess
Dec 10, 2020·Brain and Neuroscience Advances·Andrew S AlexanderMichael E Hasselmo
May 13, 2021·Cell·Salman E QasimJoshua Jacobs
Oct 19, 2021·ELife·Eloy Parra-BarreroSen Cheng
Nov 4, 2021·Current Biology : CB·Daniel BushNeil Burgess

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