PMID: 7516950Mar 1, 1994Paper

THF gamma 2 stimulates cytokine release by peripheral blood mononuclear cells of patients with chronic hepatitis B virus infection

Journal of Hepatology
H M DanielsR Williams

Abstract

A recent study indicated that thymic hormones have antiviral effects in human hepatitis B virus infection and woodchuck hepatitis virus infection. These hormones are known to exert immunomodulatory effects on lymphocyte maturation and function; because these are abnormal in patients with chronic hepatitis B virus infection, we have examined the effects of a thymic hormone (THF gamma 2) on peripheral blood mononuclear cells from patients with chronic hepatitis B virus infection. THF gamma 2 (50 or 150 ng/ml) alone was without effect; in the presence of low doses of the mitogen phytohaemagglutinin, it had a broad effect in patients and controls. The effect on interleukin-2 production was greater in patients than controls with a significant increase in production at 150 ng/ml for patients alone (p = 0.037). Tumour necrosis factor alpha production was enhanced in all patients and controls, with a greater effect seen at 150 ng/ml THF gamma 2 than 50 ng/ml. There was no effect on interferon gamma production or on the expression of membrane markers of T-cell activation. THF gamma 2 has substantial immunomodulatory activity in chronic hepatitis B virus carriers and in vivo assessment of THF gamma 2 in chronic hepatitis B virus is indic...Continue Reading

References

Jan 1, 1979·Annals of the New York Academy of Sciences·N TraininR Zaizov
Jan 1, 1979·The American Journal of the Medical Sciences·R E SamplinerJ Boitnott
Jan 1, 1992·Digestive Diseases and Sciences·C García-MonzónF Sánchez-Madrid
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G MutchnickD A Shafritz
Jan 1, 1990·International Journal of Immunopharmacology·K D LeichtlingM B Sztein
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S VentoR Williams
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G DusheikoM Kew

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Citations

Jun 1, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F RosinaM Rizzetto

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