PMID: 6984024Jan 1, 1982Paper

Thiabendazole (TBZ), an immunohemomodulator. I. Effects on lymph node and spleen

International Journal of Immunopharmacology
E DonskayaI Goldschneider

Abstract

Previous studies in our laboratory with Thiabendazole (TBZ) indicated that the drug significantly augmented cellular immune responses in mice. The purpose of the present and companion study was to determine which of the cell populations in primary and secondary lymphoid organs and in bone marrow were affected by the in-vivo administration of TBZ. Two major changes in lymph nodes and/or spleens of TBZ-treated mice were detected by histological and quantitative planimetric analysis: (1) expansion of T and B lymphocyte compartments and (2) increase in extramedullary hemopoiesis. The effect on T cells and on hemopoiesis were observed only when TBZ was administered with the thymus-dependent neoantigen, dinitrofluorobenzene (DNFB). The effect on B cells appeared to be antigen-independent. Increased extramedullary hemopoiesis in TBZ + DNFB-treated mice was preceded by a significant increase in pluripotent hemopoietic stem cell activity in bone marrow, as measured by the CFU-S assay. This study indicates that TBZ has significant effects on the development and differentiation of both lymphoid and hemopoietic cells.

References

Aug 1, 1977·Transplantation·E J Lovett, J Lundy
Aug 1, 1978·British Journal of Urology·M O SymesC R Tribe
Jan 9, 1975·The New England Journal of Medicine·D W WaraA J Ammann
Jul 1, 1966·Toxicology and Applied Pharmacology·D J ToccoH J Robinson
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F G Staber, D Metcalf
Jan 1, 1982·International Journal of Immunopharmacology·E DonskayaR Simon

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Citations

Dec 1, 1984·Agents and Actions·M L ToivonenH Vapaatalo
Jan 1, 1982·International Journal of Immunopharmacology·E DonskayaR Simon
Dec 8, 2005·Parasitology·M S SajidM U Iqbal

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