Thiahelicene-based inherently chiral films for enantioselective electroanalysis

Chemical Science
Serena ArnaboldiPatrizia R Mussini

Abstract

Chiral electroanalysis could be regarded as the highest recognition degree in electrochemical sensing, implying the ability to discriminate between specular images of an electroactive molecule, particularly in terms of significant peak potential difference. A groundbreaking strategy was recently proposed, based on the use of "inherently chiral" molecular selectors, with chirality and key functional properties originating from the same structural element. Large differences in peak potentials have been observed for the enantiomers of different chiral molecules, also of applicative interest, using different selectors, all of them based on atropisomeric biheteroaromatic scaffolds of axial stereogenicity. However, helicene systems also provide inherently chiral building blocks with attractive features. In this paper the enantiodiscrimination performances of enantiopure inherently chiral films obtained by electrooxidation of a thiahelicene monomer with helicoidal stereogenicity are presented for the first time. The outstanding potentialities of this novel approach are evaluated towards chiral probes with different chemical nature and bulkiness, in comparison with a representative case of the so far exploited class of inherently chira...Continue Reading

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Mar 1, 2015·Chemical Science·Serena ArnaboldiFrancesco Sannicolò

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Citations

Jul 23, 2020·Physical Chemistry Chemical Physics : PCCP·B P BloomD H Waldeck
May 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giorgia BonettiTiziana Benincori
Jan 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesca FontanaSimona Rizzo
Dec 29, 2020·Journal of the American Chemical Society·Qiang WangShu-Li You
Dec 24, 2021·ACS Measurement Science Au·Serena ArnaboldiAlexander Kuhn

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Methods Mentioned

BETA
AFM
atomic force microscopy
X-ray

Software Mentioned

Vision64
GPES

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