Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels

Molecular and Cellular Neurosciences
Julie VignisseLucien Bettendorff

Abstract

Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors with increased bioavailability, especially benfotiamine, exert neuroprotective effects not only for thiamine deficiency (TD), but also in mouse models of neurodegeneration. As it is known that AHN is impaired by stress in rodents, we exposed C57BL6/J mice to predator stress for 5 consecutive nights and studied the proliferation (number of Ki67-positive cells) and survival (number of BrdU-positive cells) of newborn immature neurons in the subgranular zone of the dentate gyrus. In stressed mice, the number of Ki67- and BrdU-positive cells was reduced compared to non-stressed animals. This reduction was prevented when the mice were treated (200mg/kg/day in drinking water for 20days) with thiamine or benfotiamine, that were recently found to prevent stress-induced behavioral changes and glycogen synthase kinase-3β (GSK-3β) upregulation in the CNS. Moreover, we show that thiamine and benfotiamine counteract stress-induced bodyweight loss and suppress stress-induced anxiety-like behavior. Both treatments induced a modest increase in the...Continue Reading

Citations

Jan 5, 2020·Stress : the International Journal on the Biology of Stress·João Pedro Costa-NunesCareen A Schroeter
Sep 17, 2019·Biochemistry. Biokhimii︠a︡·V A AleshinV I Bunik
Sep 4, 2020·Nutrients·Jose Enrique de la Rubia OrtíMaría Mar López-Rodríguez
Nov 1, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tatyana StrekalovaDaniel C Anthony
Sep 29, 2020·Experimental Gerontology·Ruan Carlos Macêdo de MoraesAndrea da Silva Torrão
Jun 3, 2021·International Journal of Molecular Sciences·Margaux SambonLucien Bettendorff

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