Thiamine Deficiency: An Important Consideration in Critically Ill Patients

The American Journal of the Medical Sciences
Pradeep AttaluriKenneth Nugent

Abstract

Thiamine is an essential cofactor for 4 enzymes involved in the production of energy (ATP) and the synthesis of essential cellular molecules. The total body stores of thiamine are relatively small, and thiamine deficiency can develop in patients secondary to inadequate nutrition, alcohol use disorders, increased urinary excretion and acute metabolic stress. Patients with sepsis are frequently thiamine deficient, and patients undergoing surgical procedures can develop thiamine deficiency. This deficiency can cause congestive heart failure, peripheral neuropathy, Wernicke's encephalopathy, Korsakoff's syndrome and gastrointestinal beriberi. In addition, thiamine deficiency can contribute to the development of intensive care unit complications, such as heart failure, delirium, critical care neuropathy, gastrointestinal dysfunction and unexplained lactic acidosis. Consequently, clinicians need to consider thiamine deficiency in patients admitted to intensive care units and the development of thiamine deficiency during the management of critically ill patients. Intravenous thiamine can correct lactic acidosis, improve cardiac function and treat delirium.

Citations

Mar 14, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ragaa Abd-Elsalam MohamedRadwa Saeed Ibrahim
Jul 19, 2019·Journal of Intensive Care Medicine·Farid SadakaJacklyn O'Brien
May 29, 2019·Critical Care Nursing Quarterly·Jacob P CountsG Morgan Jones
Jul 10, 2019·European Journal of Clinical Nutrition·Pavida PachariyanonKenneth Nugent
Feb 11, 2020·The Journal of Trauma and Acute Care Surgery·Saskya ByerlyRishi Rattan
Nov 14, 2019·International Journal of Molecular Sciences·Natasa CvetinovicJerneja Farkas
Nov 26, 2019·The American Journal of Clinical Nutrition·Bianca VoraKathleen M Giacomini
Jan 1, 2021·Journal of Tropical Pediatrics·Kumar Manish RajArushi Gahlot Saini
Dec 29, 2020·Frontiers in Systems Neuroscience·Tanuja Bordia, Natalie M Zahr
Jun 24, 2021·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Robert S ReamJeremy S Garrett
Jun 13, 2021·Journal of Critical Care·Yub Raj SedhaiMarkos G Kashiouris
Jun 14, 2021·The American Journal of the Medical Sciences·Joseph CaldwellKenneth Nugent
Jul 2, 2021·Critical Care : the Official Journal of the Critical Care Forum·Khalid Al SulaimanGhassan Al Ghamdi
Aug 2, 2021·Pediatric Research·Eric L WaldL Nelson Sanchez-Pinto
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Justyna PiechockaKrystyna Szymandera-Buszka
Aug 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Emily K HessSandra D Taylor
Sep 22, 2021·Current Opinion in Critical Care·Allan MigirovKamal Maheshwari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.